Evaluation of the Brain and Renal Regional Oxygenation Using NIRS in Preterm Infants
- Conditions
- Persistent Ductus ArteriosusPre-Term
- Registration Number
- NCT04295395
- Lead Sponsor
- Vilnius University
- Brief Summary
This study evaluates the brain and renal oxygenation using near infrared spectroscopy in preterm infants with persistent ductus arteriosus
- Detailed Description
Patent ductus arteriosus (PDA) is common in preterm infants. In the presence of a large PDA, significant systemic to pulmonary shunting occurs, which may result in pulmonary hyperperfusion and systemic hypoperfusion.
The evidence on PDA effect on brain and renal tissue oxygenation, measured by Near Infrared Spectroscopy is still controversial.
This study aims to evaluate the brain and renal oxygenation using near infrared spectroscopy (NONIN SenSmart model X-100) in 3 groups of preterm infants: 1) closed ductus arteriosus, 2) persistent ductus arteriosus, 3) hemodynamicaly significant ductus arteriosus.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
- preterm infants with gestation age of < 32 weeks
- birth weight < 1500g
- > 72 hours of age.
- cardiovascular, renal, cerebral congenital defects,
- confirmed sepsis,
- no parental consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences of the mean values of regional oxygenation of the brain and renal from Day 4 of live up to 36 weeks Cerebral and renal regional tissue oxygen saturation monitoring on the day after echocardiography was done
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Vilnius University Santaros Klinikos Neonatology Center
🇱🇹Vilnius, Lithuania
Vilnius University Santaros Klinikos Neonatology Center🇱🇹Vilnius, Lithuania