Comprehensive Lifestyle Management Programme in the Treatment of Obesity: the Get-a-Grip (GAG) Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Tampere University
- Enrollment
- 134
- Locations
- 1
- Primary Endpoint
- Change in weight (kg)
Study Overview
Brief Summary
The primary aim of this study was to examine weight reduction in primary care in obese or overweight subjects with a comorbidity that would benefit from weight loss during 1-year comprehensive lifestyle management programme including medical examinations, personalized dietary and exercise advice, guidance on shopping behaviour and food preparation, and group discussions.
Detailed Description
Obesity is associated with altered glucose and lipid metabolism, and elevated blood pressure (BP) increasing the risk of cardiovascular morbidity and mortality. Obesity-induced complications are increasingly encountered in the health care system and especially in primary care. Thus, there is a growing need for individually tailored weight management programs aiming to permanent lifestyle and dietary changes for the prevention and treatment of obesity-related health hazards.
The study investigated weight reduction during 1-year comprehensive lifestyle programme in 134 obese or overweight subjects (BMI>30, or BMI>25 with a comorbidity including diabetes, hypertension, arthrosis, asthma, chronic obstructive lung disease, sleep apnoea). The participants were recruited from the local diabetes centre and health care providers. The programme aimed at 5-10 % weight reduction utilizing exercise program supervised by personal trainer, advice on diet and on-location shopping behavior by a registered dietician, hands-on cooking classes by a professional chef, examinations by a medical doctor, and group discussions. The efficacy of the program was followed by measuring change in weight, BMI, waist circumference, fat and muscle percentage, visceral fat, and systolic and diastolic BP.
The study protocol has been approved by the ethics committee of the Pirkanmaa Hospital District (R12099).
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 69 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •BMI>25 with a co-morbidity that would benefit from weight loss (diabetes, hypertension, arthrosis, asthma, chronic obstructive lung disease, sleep apnoea)
Exclusion Criteria
- •physical condition that prevented exercise
- •abuse of alcohol or drugs
- •medical history suggesting poor adherence
- •severe concurrent disease
- •moderate to severe dementia
Arms & Interventions
Overweight and obese subjects
1-year lifestyle programme
Intervention: Lifestyle management programme (Behavioral)
Outcomes
Primary Outcomes
Change in weight (kg)
Time Frame: baseline, and months 2-3, 5-6, and 11-12
Weight was measured at baseline (month 0), and after 2-3, 5-6, and 11-12 months.
Change in waist circumference (cm)
Time Frame: baseline, and months 2-3, 5-6, and 11-12
Waist circumference was measured at baseline (month 0), and after 2-3, 5-6, and 11-12 months.
Change in body mass index (BMI) (kg/m^2)
Time Frame: baseline, and months 2-3, 5-6, and 11-12
BMI was measured at baseline (month 0), and after 2-3, 5-6, and 11-12 months.
Change in muscle mass and body fat (percentage points)
Time Frame: baseline, and months 2-3, 5-6, and 11-12
Muscle and fat percentage were measured at baseline (month 0), and after 2-3, 5-6, and 11-12 months.
Change in systolic and diastolic blood pressure (mmHg)
Time Frame: baseline, and months 2-3, 5-6, and 11-12
Blood pressure was measured at baseline (month 0), and after 2-3, 5-6, and 11-12 months.
Secondary Outcomes
- Fitness index(All participants were invited to a two-kilometer walk-test at baseline (month 0) and month 11-12)
Investigators
Ilkka Pörsti, MD
Clinical Professor
Tampere University