The Effects of Preoperative Carbohydrate Loading on Perioperative Blood Glucose Levels and Insulin Resistance in Type 2 Diabetes Mellitus Patients Undergoing Elective Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes Mellitus Type 2
- Sponsor
- Indonesia University
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- Insulin Resistance
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The goal of this clinical trial is to learn the effects of preoperative carbohydrate loading on perioperative blood glucose levels and insulin resistance in type 2 diabetes mellitus undergo elective surgery. The main questions it aims to answer are:
- Does carbohydrate loading affects perioperative blood glucose and insulin resistance in type 2 diabetes mellitus patients undergo surgery?
- How are the incident of perioperative hyperglycemia and hypoglycemia between subjects who receive placebo compared with subjects who receive carbohydrate loading
- How are the hyperglycemia-related complications comparison between two groups?
Researchers will compare the carbohydrate loading intervention to placebo (regular drinking water with zero-calorie sweetener) to see the effects of carbohydrate loading to blood glucose levels and insulin resistance (by HOMA-IR value)
Participants will:
- randomized to carbohydrate loading (CHO) group or placebo
- checked for preoperative, intraoperative, postoperative blood glucose, and preoperative and postoperative insulin level
- evaluated for any hyperglycaemia-related complications
Investigators
Aries Perdana
Staff of Departement of Anesthesiology and Intensive Care, Division of Cardiac Anesthesia
Indonesia University
Eligibility Criteria
Inclusion Criteria
- •Controlled type 2 diabetes mellitus with any treatment
- •BMI \<30 kg/m2
- •Non-major elective surgery
Exclusion Criteria
- •Subject refusal
- •Geriatric patients with frailty score \>4
- •Subjects with critical illness
- •Subjects received steroid treatment
- •Subjects received total parenteral nutrition
- •Subjects with intestinal obstruction
- •Subjects with impaired liver function
Outcomes
Primary Outcomes
Insulin Resistance
Time Frame: preoperative and 30 minutes postoperative
Calculated using Homeostasis Model Assessment Insulin Resistance (HOMA-IR), obtained from measured fasting insulin (μU/ml) × fasting glucose (mmol/l) / 22.5
Perioperative Blood Glucose Level
Time Frame: Preoperative (before intervention), 1 hour intraoperative, 30 minutes postoperative, 1 day postoperative
Blood glucose sampled from vein and capillary, measured in mg/dL
Secondary Outcomes
- Abnormal blood glucose incidence(Preoperative, 1 hour intraoperative, 30 minutes postoperative, 1 day postoperative)
- Complications(Up to 1 week postoperative or discharged from hospital stay)