NCT01169363CompletedNot Applicable
Validation of AML Proteomic Signature Associated With Clinical Response to Ara-C Based Induction Therapy in Patients 60 Years of Age or Older Using Samples From ECOG Studies 3999, 3993 and 1490
ECOG-ACRIN Cancer Research Group0 sites200 target enrollmentStarted: July 8, 2010Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 200
- Primary Endpoint
- Proportion of patients achieving a complete response to induction chemotherapy
Study Overview
Brief Summary
RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the laboratory may help doctors predict how well patients will respond to treatment.
PURPOSE: This research study is studying biomarkers in bone marrow and blood samples from older patients with acute myeloid leukemia treated with cytarabine-based therapy.
Detailed Description
OBJECTIVES:
Primary
- To validate a pre-specified proteomic classifier to predict the likelihood of complete response (CR) to cytarabine-based induction chemotherapy in older patients with non-M3 acute myeloid leukemia.
Secondary
- To identify signaling nodes associated with risk of relapse among these patients who achieve a CR to induction chemotherapy.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 60 Years to 120 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Proportion of patients achieving a complete response to induction chemotherapy
Time Frame: 1 month
Secondary Outcomes
No secondary outcomes reported
Investigators
Similar Trials
Completed
Not Applicable
S0106A, Biomarkers in Samples From Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With Cytarabine-Based ChemotherapyLeukemiaNCT01360125SWOG Cancer Research Network310
Completed
Not Applicable
S9333A Study of Blood and Bone Marrow Samples From Patients With Previously Untreated Primary Acute Myeloid LeukemiaLeukemiaNCT00899743SWOG Cancer Research Network132
Completed
Not Applicable
Biomarker Changes in Samples From Young Patients With Acute Myeloid LeukemiaLeukemiaNCT01139931Children's Oncology Group15
Completed
Not Applicable
Biomarkers to Classify Young Patients With Acute Lymphoblastic Leukemia (ALL) and Remission Induction Therapy in Young Patients With B-Precursor ALLLeukemiaNCT01225874Children's Oncology Group3,762
Completed
Not Applicable
S0106B Studying Bone Marrow Samples From Women With Acute Myeloid LeukemiaLeukemiaNCT01575535SWOG Cancer Research Network100