Chronic Pain Predictors in Major Trauma

Not yet recruiting

• Conditions: Limb Fracture; Chronic Pain

• Registration Number: NCT07237152
• Lead Sponsor: University of Nottingham

Brief Summary

The goal of this observational study is to learn about who is at risk of developing chronic pain in a major trauma population with at least one limb fracture.

The main question it aims to answer is: which risk factors predict which patients will experience chronic pain following traumatic limb injury.

Participants will answer a baseline questionnaire and two outcome questionnaires about their pain at 3 and 6 months after their injury.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-10
• Study First Submitted: 2025-11-14
• Study First Submitted QC: 2025-11-14
• Last Update Submitted: 2025-11-14
• Study First Posted: 2025-11-19
• Last Update Posted: 2025-11-19
• Study Start: 2025-12-01
• Primary Completion: 2027-10
• Study Completion: 2027-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

Aged ≥ 16 Polytrauma patient (multiple injuries affecting multiple body regions or organ systems) Admitted to a UK Major Trauma Centre Minimum of 1 radiologically confirmed traumatic limb fracture Have capacity to provide informed consent to participate in the study Have sufficient proficiency in English to provide the required data or be willing to use an approved interpreting service for data collection Recruited within 4 weeks of injury

Exclusion Criteria

No traumatic limb fracture Patients with a primary or treatment amputation in relation to their limb injury Pathological limb fractures Prisoners No fixed abode

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of chronic pain	Reported at baseline, 3 and 6 months post-injury	Assessed using a 11-point numerical rating scale from 0 (no pain) - 10 (worst possible pain).
Severity of chronic pain	Reported at baseline, 3 and 6 months post-injury	Assessed using a 11-point numerical rating scale from 0 (no pain) - 10 (worst possible pain).
Pain impact	Reported at baseline, 3 and 6 months post-injury	Assessed using the six-item pain interference index

Trial Locations

Locations (1)

Queens Medical Centre- Nottingham University Hospitals NHS Trust; 🇬🇧 Nottingham, Nottinghamshire, United Kingdom