Maximal Rate of Force Development of Ankle Muscles and Functional Ability in Patients With Knee Osteoarthritis

Completed

• Conditions: Knee Osteoarthritis; Knee Arthritis
• Interventions: Diagnostic Test: Maximal Rate of Force Development Test for Ankle Muscles

• Registration Number: NCT06063889
• Lead Sponsor: Ahram Canadian University

Brief Summary

This study is a detailed assessment of the maximal rate of force development of ankle muscles and its association with functional ability in patients with knee osteoarthritis (OA).

Detailed Description

This research is designed to study the link between force development in ankle muscles and functional abilities in knee OA patients. It aims to understand the influence of ankle muscle strength, specifically plantar flexors, on the stability, pain, and functionality of patients with knee OA. The study will analyze the rate of force development, its importance in explosive strength improvement, and impact on preventing knee injuries. Furthermore, it will investigate the compensatory mechanism of the plantar flexors developed by patients in advanced stages to balance other muscle failures.

Study Timeline

• Study Start: 2023-07-20
• Study First Submitted: 2023-09-26
• Study First Submitted QC: 2023-09-26
• Study First Posted: 2023-10-03
• Primary Completion: 2024-02-02
• Study Completion: 2024-02-02
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-05
• Last Update Posted: 2024-08-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

• Group 1 (Knee OA group)

  1. Patients diagnosed with knee osteoarthritis according to Performance of the 2018 classification criteria for early stage knee OA was tested using data from the Osteoarthritis Initiative (OAI (Leung et al.,2020).
  2. Grade 2-3 KOA cases according to Kelgren-Lawrance classification
  3. Having knee pain for at least 6 months.
  4. The visual analog scale (VAS) score being at least 3 or more.

• Group 2 (Healthy control group) 1. Individuals with no signs or symptoms of Knee OA or other neurological or musculoskeletal conditions.

Exclusion Criteria

1. Patellar subluxation
2. Surgery in any joint of the lower limb
3. Meniscal injury
4. Ligament instability
5. Patients who received intra-articular injection in the knee in the last 6 months
6. Patients with problems in the hip and ankle
7. Patients who participated in in another physical therapy program in the last 3 months were not included in the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Knee OA Patients	Maximal Rate of Force Development Test for Ankle Muscles	This group consists of patients who have been diagnosed with knee osteoarthritis. They will be subjected to a series of tests to assess the maximal rate of force development of ankle muscles and their functional abilities.
Healthy Control	Maximal Rate of Force Development Test for Ankle Muscles	This group will include healthy individuals without knee osteoarthritis. They will undergo the same series of tests to serve as a control group, enabling the comparison of results with the Knee OA Patients group.

Primary Outcome Measures

Name	Time	Method
Rate of Force Development (RFD)	Baseline	The RFD is a measure of the speed at which the force of a muscle contraction develops. It is typically measured during isometric contractions and provides information about the muscle's explosive strength capacity.
Single Leg Hop Test (SLHT)	Baseline	n this test, participants hop forward as far as possible on one leg, and the distance hopped is recorded.
Knee Osteoarthritis Outcome Score (KOOS)	Baseline	The KOOS is a questionnaire that assesses five aspects of knee injury and osteoarthritis: pain, symptoms, ADL function, sport and recreation function, and quality of life. Scores are transformed to a 0-100 scale, with zero representing extreme knee problems and 100 representing no knee problems. Higher scores indicate better function and less pain.
Forward Step Down Test (FSDT)	Baseline	This functional ability test requires participants to perform as many repetitions as possible in 30 seconds of a specific movement. The number of valid repetitions performed in this duration is recorded.
Isokinetic Testing Procedures	Baseline	This procedure involves conducting tests of three (60°/s) or five (120°/s) maximal nonconsecutive efforts with specific rest intervals. Each subject is instructed to exert maximal effort throughout the whole range of motion.

Trial Locations

Locations (1)

Outpatient clinic of faculty of physical therapy, Ahram Canadian University; 🇪🇬 Al Ḩayy Ath Thāmin, Giza, Egypt