跳至主要内容
临床试验/CTRI/2023/09/057902
CTRI/2023/09/057902尚未招募不适用

Correlation of left ventricular ejection fraction with cardiac troponin I and serum ferritin levels in acute ST elevation myocardial infarction patients.

GGSMCH FARIDKOT1 个研究点 分布在 1 个国家目标入组 75 人开始时间: 2023年1月10日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
75
试验地点
1
主要终点
Troponin I levels

研究概览

简要总结

India has the highest burden of Acute Coronary Syndrome (ACS) patients in the world. Indian Patients who suffer from ACS are relatively younger and have a  significantly higher proportion  of ST-elevation myocardial infarction (STEMI) as compared to patients in developed countries. It is estimated that more than 3 million STEMI occurs every year in India. The measurement of left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI) is a class I clinical practice guideline recommendation, and  has both prognostic and therapeutic implications. Reduced LVEF is associated with greater mortality in patients with coronary artery disease and predicts increased risks of early mortality, as well as sudden cardiac death. Serum ferritin is an acute phase reactant and is considered to be a risk factor for MI. High serum ferritin may increase the risk of MI in the presence of other risk factors that increase the formation of free radicals, thus accelerating atherogenesis through stimulation of low-density lipoprotein oxidation. So, the aim of the study is to find the correlation of troponin I and ferritin levels with left ventricular ejection fraction in ST elevation MI patients presenting to the hospital.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • 1.Acute onset MI as diagnosed by typical clinical presentation.
  • ECG characteristics specific of STEMI.

排除标准

  • 1.Previous history of myocardial infarction.
  • 2.A patient having pre existing ECG changes s/o old MI or ECG showing Q wave at the time of admission.
  • LVH, conduction defects, heart blocks.
  • Conditions in which Troponin I levels increases irrespective of heart disease.: renal impairment, rheumatoid arthritis, pericarditis, spesis, acute congestive heart failure, acute pulmonary embolism, or prolonged tachyarrythmias.
  • Hemochromatosis, liver disease, TB, patients on iron supplements.

结局指标

主要结局

Troponin I levels

时间窗: baseline

S. ferritin levels

时间窗: baseline

Left ventricular ejection fraction

时间窗: baseline

次要结局

  • Correlation OF S. ferritin & troponin I levels along with their correlation with left ventricular ejection fraction(baseline)

研究者

发起方
GGSMCH FARIDKOT
申办方类型
Government medical college

研究点 (1)

Loading locations...

相似试验