Study on treatment options for patients with reflux esophagitis who are refractory to proton pump inhibitor administration. - Study on treatment for patients with refractory reflux esophagitis with proton pump inhibitors.

Department of Gastroenterology and Hepatology, Kansai Medical University0 个研究点目标入组 60 人开始时间: 2010年4月1日最近更新: 2023年10月17日

试验速览

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•(1) Patients who are under 20 years of age. (2) Patients who are allergic to the ingredient of the test drugs. (3) Patients who underwent an operation of intestinal resection or vagotomy. (4) Patients who have alert symptoms such as nausea, gastrointestinal bleeding and rapid body weight loss. (5). Patients who had previous medical history of or suffer from the following diseases:Zollinger-Ellison syndrome, inflammatory bowel disease, irritable bowel disease, esophageal stenosis, esophageal achalasia, malabsorption, cerebrovascular disease such as cerebral hemorrhage, cerebral infarction. (6) Patient who can not participate the study due to the coexistence of the diseases such as severe liver, renal or heart diseases. (7) Patients who have malignancy or suspected malignancy (Cured patients are eligible). (8) Patients who are pregnant, in breast-feeding, or may be pregnant. (9) Patients who need continuous medication with drugs that are contraindication or dangerous to the combination with the test drug. (10) Patients who take proton pump inhibitors except ransoprazole. (11) Patients who take drugs that may affect the evaluation of the test drug (Patients who take such drugs without changing the usage or doses during the study period are eligible). (12) Patients who are not considered to be eligible for the study by the doctor's judgment.

发起方

Department of Gastroenterology and Hepatology, Kansai Medical University