Comparison of The Routine Respiratory and Gradual Device-guided Slow Breathing Exercises on Inflammation and Heart Rate Variability in Patients With Heart Failure

Not Applicable

Conditions: Chronic heart Failure.
Heart failure

Registration Number: IRCT20210426051093N1

Lead Sponsor: Tarbiat Modares University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 36

Inclusion Criteria

Class II and III heart failure based on NYHA criteria
Having suffered from heart failure for the past 3–5 years
Clinical status and stable hemodynamics at least one month before entering the study
Ejection fraction less than 50% based on echocardiography
Being treated with standard medication
Age range: 50 to 70 years

Exclusion Criteria

Unstable angina and complex ventricular arrhythmias
The occurrence of myocardial infarction in the past year
having pacemaker
During the last six months, have bypass surgery or angioplasty.
Participate in other exercise programs six months before the start of the study.
The existence of musculoskeletal disorders that prevent normal walking
Existence of cognitive disorders
Lack of personal desire to cooperate
History of lung disease, smoking, angina, heart attack or heart surgery (less than six months), orthopedic or neurological diseases, steroid therapy, or chemotherapy

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The basic rate of respiration. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: Average rate of five minutes of respiration based on respirometer biofeedback.;Inflammation. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: According to the report of TNF-alpha in an enzyme-linked immunosorbent assay device.;Heart Rate Variability. Timepoint: 48 hours before the intervention and 48 hours after the end of four weeks of intervention. Method of measurement: Holter monitoring device.

Secondary Outcome Measures