Cognitive, Functional, and Psychosocial Outcome After Mild Traumatic Brain Injury: a Cross-sectional Study at a Tertiary Care Trauma Center.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 360
- 试验地点
- 1
- 主要终点
- Mini-Mental State Examination
研究概览
简要总结
Patients with traumatic brain injury are likely to present with cognitive, psychological, emotional and behavioral problems during different periods, all of which affect patients' life quality seriously. The aim of this study was to assess cognitive and psychosocial outcome in patients with mild traumatic brain injury, and to determine the risk factors associated with cognitive and psychological outcome. Mini-mental state examination (MMSE), activities of daily living scale (ADL), the Hospital Anxiety Depression Scale (HADS) and mental health symptom checklist (SCL-90) were used to assess the cognitive performance and psychological outcomes in 360 patients with mild traumatic brain injury. Chi-square, Fisher's exact tests and Logistic regression analysis were used to analyze the risk factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 ~ 60 years old
- •Education: primary school and above, who could understand the content of psychological test
- •History of brain trauma
- •No taking of antipsychotic or any other drugs affecting central nervous system before the test
- •Glasgow coma score (GCS) was 13-15
排除标准
- •History of craniocerebral injury, brain disease, mental disease
- •With mental retardation
- •with other serious body diseases
- •History of drug and alcohol dependence
- •With color-blind or color weakness
- •Who had severe visual and auditory disorders after brain injury
- •Who failed or failed in completing the test effectively
- •With cognitive impairment caused by the damage of the unilateral frontal or bilateral lobes, or with language dysfunction caused by temporal lobe damage
结局指标
主要结局
Mini-Mental State Examination
时间窗: 6 months
MMSE includes seven factors, namely: the time orientation factor (5 points), place orientation (5 points), immediate memory (3 points), short-term memory (3 points), calculation capabilities (5 points), verbal expression, naming and repetition (4 points), speech reading and understanding (4 points), graphic depiction (1 points). The scales for the description of cognitive function impairment were grouped into three levels of education: illiteracy (17 points), primary school (20 points) and middle school (24 points). The one with score below average was considered with cognitive function impairment.
次要结局
- Activity of daily living scale(6 months)
研究者
Hao Chen
Doctor
Shanghai 6th People's Hospital