Single Embryo TrAnsfeR of Euploid Embryo
- Conditions
- AneuploidyInfertility
- Registration Number
- NCT02268786
- Lead Sponsor
- Illumina, Inc.
- Brief Summary
The purpose of the current study is to evaluate the effect of preimplantation genetic screening (PGS) by next generation sequencing (NGS) compared to standard morphological assessment of embryos on pregnancy rates through a randomized controlled trial (RCT). All embryos will be vitrified and a single embryo transfer (SET) will be performed with either screened or unscreened embryos depending on randomization.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 661
- Patient undergoing IVF
- At least 2 blastocysts suitable for biopsy on day 5 or 6 of embryo development
- History of more than two prior implantation failure following IVF
- History of more than one miscarriage of viable pregnancy
- One or both partners known to be carrier(s) of a chromosomal abnormality
- Known genetic carrier couple and/or one or both partners carrier of a known autosomal dominant disorder
- Any other non-study related preimplantation genetic testing
- Use of donor oocytes
- Use of gestational carrier (surrogate or donor egg recipient).
- Severe oligospermia (<1,000,000 sperm/ml); Surgical Sperm Retrieval for reasons other than post-vasectomy and CAVD
- Low ovarian reserve with (FSH) >10 IU/L on day 2-4 of a prior menstrual cycle and/or (AMH) <7 pmol/L (or <1 ng/ml)
- Gender selection cycles
- Concurrent participation in another clinical trial
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Ongoing Pregnancy Gestational Age of 20 Weeks Number of Participants with Ongoing Pregnancy at 20 Weeks Gestation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (37)
Fertility Treatment Center
🇺🇸Tempe, Arizona, United States
HRC Fertility
🇺🇸Encino, California, United States
Acacio Fertility Clinic
🇺🇸Laguna Niguel, California, United States
HRC Fertility Pasadena
🇺🇸Pasadena, California, United States
Fertility Specialists Medical Group
🇺🇸San Diego, California, United States
Reproductive Science Center of San Francisco Bay Area
🇺🇸San Ramon, California, United States
Colorado Center for Reproductive Medicine (CCRM)
🇺🇸Lonetree, Colorado, United States
Reproductive Associates of Delaware
🇺🇸Newark, Delaware, United States
CRM Orlando
🇺🇸Orlando, Florida, United States
Georgia Reproductive Specialists
🇺🇸Atlanta, Georgia, United States
Scroll for more (27 remaining)Fertility Treatment Center🇺🇸Tempe, Arizona, United States