Effect of vitamin C supplementation on circulating microRNA in type 2 diabetic patients with poor glycemic control
Phase 1
Active, not recruiting
- Conditions
- The participants of this study are type 2 diabetic patients.All of the T2DM patients were ancillary to the vitamin C projectEffects of vitamin C on metabolism and oxidative stress in patients with t
- Registration Number
- TCTR20191119002
- Lead Sponsor
- The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associ
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
Having type 2 diabetes mellitus for at least 12 months, with poor glycemic control (HbA1c ≥8.5%), being treated with oral diabetic drugs only (no insulin injection), receiving lipid-lowing drugs or anti-hypertensive drugs, sedentary and lack of any regular exercise program for at least 6 months and living in Khon Kaen Province, Thailand. For microRNA study, Blood samples from the patients who increased plasma vitamin C levels and phagocytosis activity as well reduced oxidative stress at post-vitamin C supplementation compared to pre-supplement (results from the previous study in our lab group) were selected to investigate microRNA expression.
Exclusion Criteria
Failed to increase vitamin C levels after the vitamin C intervention
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method circulating microRNA expression Before and after 6 weeks of the intervention microRNA microarray
- Secondary Outcome Measures
Name Time Method circulating microRNA expression Before and after 6 weeks of the intervention qRT-PCR