Resistance exercise and artery functio

Not Applicable

• Conditions: Atherosclerosis; Stroke; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12624000876594
• Lead Sponsor: Massey University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-18
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Aged between 18 and 35
- Do not partake in regular resistance exercise (RE), defined as having not completed (greater than 1 session per week for 3 consecutive weeks) dedicated resistance training (powerlifting, weightlifting, bodybuilding, or CrossFit) in the last 6 months
- Do not regularly perform rowing type exercise (greater than 1 session per week for 3 consecutive weeks) in the last 6 months. Rowing exercise produces similar sinusoidal fluctuations in blood pressure and MCAv to RE and may confer some of the same vascular adaptations. Perform less than or equal to 1 dedicated aerobic exercise session per week for greater than or equal to 6 months prior to the experiment. This does not include regular physical activity e.g. activities that would be classified as low intensity such as walking, gardening, low intensity cycling (commuting) and general household chores.

Exclusion Criteria

•Self-reported diagnosis of any heart (e.g. congestive heart failure), vascular (e.g. atherosclerosis of peripheral vascular disease) or cerebrovascular (e.g. stroke) condition
•Have recently fainted (within the last 6 months), have repeated bouts of syncope of any origin, postural hypotension or postural orthostatic tachycardia syndrome
•Self-reported diagnosis of a pulmonary disease (e.g. chronic obstructive pulmonary disease (COPD))
•Self-reported diagnosis of a metabolic disease (e.g. diabetes mellitus)
•Self-reported diagnosis of a musculoskeletal or other soft tissue injury that may inhibit the completing of resistance exercise (e.g. previous fractures, or ligament, tendon, or muscle sprains/tears/inflammation)
•Have been told by their doctor that they should not exercise for any reason
•Are pregnant
•Currently smoke or vape, or have done so in the last 6 months
•Are taking any medications to control heart rate or blood pressure
•Have sensitive/irritable skin or a skin disease (infectious or non-infectious)
•Have any other reason to consider that they are not in good health and should not exercise
•Are unable to complete the exercises detailed in the study protocol (leg press, chest press, bicep curl, leg extension or squat stand)
•Any medical condition which, at the Investigator’s discretion, may present a safety risk or impact the feasibility of the study or study results.
•Additionally, participants will not be included in the study if the study team are unable to obtain an adequate blood velocity signal from the middle cerebral artery. The course of the middle cerebral artery can vary between individuals and obtaining an adequate signal in individuals with a tortuous middle cerebral artery can be difficult.

Study & Design

• Study Type: Interventional
• Study Design: Not specified