A Comparative Study of Two Different Types of Dexamethasone for Pain Management After Knee Joint Replacement Surgery

Not Applicable

• Conditions: Diseases of the musculoskeletal system and connective tissue

• Registration Number: KCT0009362
• Lead Sponsor: Korea University Ansan Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 114

Inclusion Criteria

Inclusion Criteria:
Patients diagnosed with primary osteoarthritis of the hip joint who have received symptomatic treatment (medication, physical therapy) but have not achieved adequate pain control and are scheduled to undergo hip joint replacement surgery at the hospital, who understand the research content and agree to participate in the study.

Exclusion Criteria

Exclusion Criteria:
Age below 60 or above 80 years.
Patients undergoing revision hip replacement surgery.
Joint arthritis other than primary osteoarthritis (e.g., rheumatoid arthritis, psoriatic arthritis, gouty arthritis, lupus arthritis, post-traumatic arthritis, etc.).
Hemoglobin level exceeding 8% before surgery.
Surgery performed under spinal anesthesia rather than general anesthesia.
Concurrent surgical procedures other than hip joint replacement during surgery.
Use of steroids due to the patient's underlying condition before surgery (e.g., patients undergoing steroid inhaler therapy, patients receiving steroid replacement therapy due to adrenal insufficiency, etc.).
Use of self-administered pain control devices after surgery.
Administration of steroid injections within 3 months before surgery (intravenous, intra-articular, etc.).
Use of steroids for purposes other than the study objectives during hospitalization after surgery (e.g., spinal or joint injections).
Occurrence of postoperative medical emergencies requiring additional treatment (e.g., stroke, acute coronary syndrome, acute respiratory distress syndrome).
Allergy to dexamethasone sodium phosphate or dexamethasone palmitate.
Hypersensitivity or allergy to soybean oil.
Patients with hypersensitivity to soybeans or peanuts.

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative pain, severity of postoperative nausea and vomiting (NRS), and usage of rescue medications.

Secondary Outcome Measures

Name	Time	Method
Postoperative blood sugar elevation and surgical site infection.