Are Comorbidities Related to Frequent Severe Exacerbations of AECOPD

Completed

• Conditions: Chronic Obstructive Lung Disease; Comorbidities and Coexisting Conditions; Acute Exacerbation of COPD
• Interventions: Other: Frequency of AECOPD

• Registration Number: NCT05504993
• Lead Sponsor: Ankara University

Brief Summary

INTRODUCTION: Relationship between comorbidities and COPD is two-sided. While the number of comorbidities increasing, the frequency of acute exacerbations of COPD (AECOPD) is increasing, too. Comorbidity indexes can be used for recognition of comorbidities while managing COPD patients. In the present study, it is aimed to compare comorbidity indexes such as Charlson Comorbidity Index, COMCOLD and COTE in the matter of exacerbation frequency.

METHOD: Subjects hospitalized for AECOPD, admitted to the study. Exacerbation severity, frequency, further exacerbations for a 1-year period in the follow-up period and CCI, COMCOLD and COTE scores were recorded. High and low comorbidity groups were compared for AECOPD frequency, severity, and further exacerbations.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2018-07-01
• Study Completion: 2022-01-01
• Status Verified: 2022-08
• Study First Submitted: 2022-08-14
• Study First Submitted QC: 2022-08-16
• Last Update Submitted: 2022-08-16
• Study First Posted: 2022-08-17
• Last Update Posted: 2022-08-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

• COPD patients
• Admitted to the ward for AECOPD

Exclusion Criteria

• Not giving informed consent
• Unable to perform PFT
• Lost to follow-up

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
High comorbidity group	Frequency of AECOPD	CCI equal or higher than 2 COTE equal or higher than 4 COMCOLD equal or higher than 4
Low comorbidity group	Frequency of AECOPD	CCI lower than 2 COTE lower than 4 COMCOLD lower than 4

Primary Outcome Measures

Name	Time	Method
Frequency of AECOPD	1 year	Frequency of AECOPD in the last one year

Secondary Outcome Measures

Name	Time	Method
Having at least one severe AECOPD	1 year	having at least one severe AECOPD in the last year
Frequency of AECOPD for the next one year	1 year	the number of AECOPD for 1 year period from the preceding admission, regardless of severity

Trial Locations

Locations (1)

Ankara University Faculty of Medicine; 🇹🇷 Ankara, Turkey