NL-OMON36495已完成4 期
Pharmacokinetics of the addition of an acidic beverage to posaconazole co-administered with a proton pump inhibitor in GVHD patients - Pharmokinetics of cola addition to posaconazol and PPI in GVHD
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 16
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •*recipients of hematopoietic stem-cell transplantation (HSCT) with graft versus host disease (GVHD) using PPI
- •*start or use of posaconazole for invasive fungal infection (IFI) prophylaxis with concomitant PPI use for at least twelve days or one week when already using posaconazole
排除标准
- •*current clinical significant invasive fungal infection requiring treatment
- •*inability to sign informed consent
- •*inability to take oral medication
- •*allergy to posaconazole, PPI or the acidic beverage
- •*start or discontinuation of a CYP3a4 inhibitor or P-glycoprotein inducer during the study period
- •*age < 18 years
- •*grade II or more diarrhea, mucositis, vomiting
研究者
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