Protists and Nematodes Fish Parasites: From Their Circulation in Ecosystems to Their Impact on Human Health - Prevalence of Fish Allergy in Occupational Settings.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 486
- 试验地点
- 4
- 主要终点
- The prevalence of fish allergy
研究概览
简要总结
Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic agents, and have a high impact on human health.
Infestation results from the ingestion of living larvae from contaminated fishes. It can be asymptomatic or symptomatic, resulting in acute gastric, acute intestinal or chronic forms. Allergic manifestations are frequently encountered in gastric forms, but isolated allergic symptoms can occur after ingestion of Anisakidae antigens in raw or cooked fish. Cutaneous contact or Anisakis allergen inhalation have also been reported to induce allergy/anaphylactic reactions or sensitization in the occupational setting in Spain, Italy, Sicilia or South Africa. But no data is available in France.
In this context, the investigators propose to determine and compare the frequency and characteristics of fish allergy in fish workers (fishermen and fish-processing factory workers) and a control population of workers without occupational exposure to fish, in Boulogne-sur-Mer, which is an important fishing port in France, and the first European center for fish processing.
详细描述
162 fishermen, 162 fish-processing factory workers, and 162 control subjects will be consecutively recruited by their occupational doctor during a routine consultation. A standardized questionnaire will be used to collect epidemiological and clinical data on potential allergic manifestation resulting from digestive, cutaneous, or respiratory contact with fish. Domestic and occupational risk factors for fish and Anisakis exposure will also be collected for both allergic and non-allergic patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Fisherman followed by the "Service de Santé des Gens de Mer" of Boulogne-sur-Mer, fish-processing factory worker followed by the "Service de Santé au Travail" of Boulogne-sur-Mer, or worker followed by the "Service de Santé au Travail" of Boulogne-sur-Mer, but not working in a fish-processing factory.
排除标准
- •Pregnant or breast-feeding female
- •Patient with no social insurance
- •Patient unwilling to comply with the protocol
- •Patient unable to understand the study and its objectives
- •Patient under guardianship
研究组 & 干预措施
Fish processing factories
Workers of fish processing factories who are followed by the "Service de Santé au Travail" (ASTIL) of Boulogne-sur-Mer, France (occupational exposure to fish).
A questionnaire will be completed.
干预措施: Questionnaire (Other)
Control
Workers who are followed by the "Service de Santé au Travail" (ASTIL) of Boulogne-sur-Mer, France, but do not work in fish processing factories.
A questionnaire will be completed.
干预措施: Questionnaire (Other)
Fishermen
Fisherman followed by the "Service de Santé des Gens de Mer" of Boulogne-sur-Mer, France (occupational exposure to fish).
A questionnaire will be completed.
干预措施: Questionnaire (Other)
结局指标
主要结局
The prevalence of fish allergy
时间窗: contact by phone during 30 min at only visit (inclusion)
Difference in the prevalence of fish allergy between occupationally exposed (fishermen and fish-processing factory workers) and non-exposed subjects. the fish allergy is definied by clinical diagnosis based on the presence of clinical manifestations of allergy in contact with the fish ( APC)
次要结局
- Frequencies history of infections Anisakis spp.(contact by phone during 30 min at only visit (inclusion))
- Frequency of fish allergies, history of infections Anisakis spp. (clinical diagnosis)(contact by phone during 30 min at only visit (inclusion))
- history of infections Anisakis spp. (clinical diagnosis)(contact by phone during 30 min at only visit (inclusion))
- Frequency of risk factors for occupational or domestic exposure to fish:(contact by phone during 30 min at only visit (inclusion))