Astigmatism in Keratoconus Patients

Not Applicable

• Conditions: Keratoconus
• Interventions: Device: Pentacam

• Registration Number: NCT03450213
• Lead Sponsor: Assiut University

Brief Summary

Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning, resulting in a cone-like bulge , which causing irregular astigmatism and vision impairment.

Detailed Description

Keratoconus is the most common form of corneal ectasia, with an incidence of 50-230 per 100,000 persons.Pentacam used diagnose \& detect the progression in patients with keratoconus and also provide a detailed information about corneal tomography and topography.

In the last few years, it has been shown that in healthy individuals the posterior corneal surface has not only a different amount of astigmatism but also a different alignment of the steep meridian.

The aim of this research is to compare the amount and axis alignment of anterior and posterior corneal astigmatism in keratoconus with a healthy controlled group .

Study Timeline

• Study First Submitted: 2018-02-23
• Study First Submitted QC: 2018-02-27
• Study First Posted: 2018-03-01
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-15
• Last Update Posted: 2018-10-17
• Study Start: 2019-10-01
• Primary Completion: 2020-10-01
• Study Completion: 2021-10-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients diagnosed with keratoconus using the following criteria:

Specific diagnostic signs is asymmetric refractive errors with high progressive or irregular astigmatism, and elevated keratometry values, scissoring of the red reflex, Vogt striae, Fleischer rings, inferior or central steepening on topography with abnormal localized steepening .

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Exclusion Criteria

• Unwillingness to participate in the study .
• Corneal scarring.
• Any ectatic conditions that were not explicitly keratoconus such as keratoglobus and pellucid marginal degeneration .
• Previous ocular surgery.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients with keratoconus	Pentacam	Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex.
Normal people at the same age and sex	Pentacam	Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex.

Primary Outcome Measures

Name	Time	Method
Comparison between astigmatism in patients with keratoconus and normal people.	Two years	Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex