Randomised double blind,placebo controlled evaluation of NANO KANCHANAR (Bauhinia variegata Linn)HYDRO ALCOHOLIC EXTRACT in HYPOTHYROIDISM

Hypothyroidism is a disorder that occurs when the thyroid gland does not make enough thyroid hormones to meet the body’s need. The thyroid hormone regulates metabolism—the way the body uses energy— and affects nearly every organ in the body. Without enough thyroid hormone, many of the body’s functions slowdown.

There is no direct description of hypothyroidism in Ayurveda but on the basis of its clinical presentation hypothyroidism can be correlated with dhatwagnimandya (ras and meda dhatwagnimandya). Samprapti Ghataka’s are Kapha Dushti, Dhatwagnimandya, Jatharagni Dushti Rasavaha - Medovaha Sroto- Dushti found mainly. So, Hypothyroidism is a Santarpanjanya Vyadhi

Kanchanara reduce the swelling of neck, increased serum thyroid hormone concentration, decreased Cholestrol and improve Thyroid histology Kanchnar is considered as a drug of choice for Granthi vikar and Galaganda, hence for the present study hydroalcoholic extract Kanchnar Twak is selected. Kanchnar stem bark has been investigated and reported to have anti-tumor property. Kanchnar extract, as standardized extracts, provide unlimited opportunities for uncovering new drug because of the unmatched availability of chemical diversity.

It is expected that by using Nano particles bioavailability, effectiveness is enhanced. The dosage of drug which is difficult to take will be reduced without reducing the quality and effect of the drug. As this will be a new dosage form of B.variegata stem bark, safety and efficacy which is established by previous studies in animal models, will be evaluated in cases of hypothyroidism.May increase bioavailability, easily palatable, effectiveness is more Reduced exploitation of plants as the size of herbal medicine is reduced. Increase the therapeutic value by reducing toxicity level of the drug.