Predictive factors and pharmacokinetics of intraperitonal chemotherapy
Phase 2
Completed
- Conditions
- Ovarian cancer10038594
- Registration Number
- NL-OMON42305
- Lead Sponsor
- Medische Oncologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
Primary epitelial ovarían carcinoma FIGO stage III
Optimal primary debulking (tumor rests <=1cm )
WHO 0-2
Adequate hematological, renal and liver function tests, conform standard protocol for chemotherapy
Creatinine clearance >60 ml/min (Cockroft)
Bilirubin and/or transaminases < 1,25 UNL
WBC>= 3. 10^6/L en Platelets >= 100. 10^6/L
Exclusion Criteria
Intestinal stoma proximal to the flexura lienalis
Sepsis postoperative after primary debulking
Extended intraperitoneal adhesions
Neurotoxicity grade >1
Previous chemotherapy for ovarian carcinoma
Symptomatic hearing loss
Age >70 years old
Haemoglobin < 6.0 mmol/L
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method