Near Infrared Spectroscopy in Sickle Cell Pediatric Patients
Withdrawn
- Conditions
- Sickle Cell Disease
- Registration Number
- NCT04031521
- Lead Sponsor
- Children's National Research Institute
- Brief Summary
Endothelial dysfunction contributes to vaso-occlusion and acute pain in sickle cell disease. Near infrared spectroscopy (NIRS) technology can measure tissue oxygenation and endothelial function. The main objective of this study is to study the natural history of tissue muscle oxygenation using NIRS in pediatric sickle cell subjects experiencing acute pain and pediatric sickle cell patients in steady-state.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tissue oxygenation 6 months
- Secondary Outcome Measures
Name Time Method Nitric oxide 6 months
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link NIRS-measured tissue oxygenation to endothelial dysfunction in sickle cell disease?
How does NIRS compare to standard-of-care methods in assessing muscle oxygenation during sickle cell pain crises?
Which biomarkers correlate with NIRS outcomes in pediatric sickle cell patients during acute pain episodes?
What adverse events are associated with NIRS monitoring in children with sickle cell disease and how are they managed?
Are there combination approaches integrating NIRS with other diagnostics to improve sickle cell disease management?
Trial Locations
- Locations (1)
Children's National Medical Center
🇺🇸Washington, District of Columbia, United States
Children's National Medical Center🇺🇸Washington, District of Columbia, United States