Covid-19 Pediatric Observatory
- Conditions
- COVID-19
- Interventions
- Other: hospitalized children with Covid19
- Registration Number
- NCT04336956
- Lead Sponsor
- Centre Hospitalier Intercommunal Creteil
- Brief Summary
In early December 2019, cases of pneumonia of unknown origin were reported in Wuhan, Hubei Province in the People's Republic of China. The disease spreads rapidly and the number of sick people is increasing. On January 3, 2020 a new virus of the coronavirus family is identified in samples of bronchoalveolar lavage fluid from a patient in Wuhan and subsequently confirmed as the cause of these pneumonias. On 7 January 2020, the World Health Organization (WHO) designated it as the new coronavirus 2019 (i.e. 2019-nCoV). On 11 February 2020, the WHO designated the disease associated with 2019-nCoV as coronavirus 2019 disease (COVID-19). On 12 March, WHO announced that the COVID-19 outbreak is a pandemic.
As of March 24, 2020, more than 375,000 cases of COVID-19 had been diagnosed with more than 16,000 deaths attributed to this virus. (Ref WHO https://www.who.int/emergencies/diseases/novel-coronavirus-2019 ).
In France, the number of cases rose from 105 cases at the end of February to 19615 confirmed cases on March 24. (Source Public Health France). Most of the cases are adults. However, children are not completely spared and serious cases have been described. These severe cases can be respiratory or extra-respiratory (e.g. myocarditis). We also know that pediatric and adult cases differ in terms of clinical, biological and imaging findings, particularly chest CT scans. However, the description of paediatric pictures, especially severe forms and the involvement of children suffering from co-morbidities, remains poorly reported. Finally, the risk factors for serious cases in children remain largely unknown.
This observatory aim to describe the clinical phenotypes of hospitalized pediatric patients with Covid19 in France, according to age groups. Moreover for a subgroup of patients, informations regarding the long covid will be reported.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 5000
- Children < 18 years old
- Admitted in French pediatric wards
- With a confirmed COVID-19 infection. ( on Nasal and pharyngeal swab specimens or blood samples tested positive for 2019-nCoV nucleic acid using real-time reverse-transcriptase polymerase-chain-reaction (RT- PCR) assay; or on typical chest CT signs
- Expressed refusal to participate
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description hospitalized children with Covid19 hospitalized children with Covid19 - Children \< 18 years old Patients under 18 years old, admitted in French pediatric wards with a confirmed COVID-19 infection on Nasal and pharyngeal swab specimens or blood samples tested positive for 2019-nCoV nucleic acid using real-time reverse-transcriptase polymerase-chain-reaction (RT- PCR) assay; or on typical chest CT signs
- Primary Outcome Measures
Name Time Method Percentage of children with severe or critical form. Day 14
- Secondary Outcome Measures
Name Time Method Pulmonary echography Day 14 requiring intensive care support or not
Clinical symptoms of children day 14 requiring intensive care support or not
Evaluation of long covid up to 12months Percentage of children requiring intensive care support at day 14 CT chest of children at admission requiring intensive care support or not
Biological results of children day 14 requiring intensive care support or not
nasopharynx SARScov2 PCR at admission number of hospital days up to 12months days
nasopharynx multiplex PCR at admission if available
nasopharynx sarscov2 load at day 7 if available
Trial Locations
- Locations (76)
Ch de Saint Malo
🇫🇷Saint-Malo, France
CHRU de Nancy
🇫🇷Nancy, France
POISSY - CH de POISSY
🇫🇷Poissy, France
Hopital Arnaud de Villeneuve
🇫🇷Montpellier, France
Ch de Neuilly Sur Seine
🇫🇷Neuilly-sur-Seine, France
CH Bel Air
🇫🇷Thionville, France
CH de Montargis
🇫🇷Montargis, France
Nantes - Hopital Mere Enfant
🇫🇷Nantes, France
Chr Orleans
🇫🇷Orléans, France
Hopital St Jean Roussillon
🇫🇷Perpignan, France
Assistance Publique Hôpitaux de Paris
🇫🇷Paris, France
Hopital Lenval
🇫🇷Nice, France
Hopital Sainte Musse
🇫🇷Toulon, France
CH de MONTBRISON
🇫🇷Montbrison, France
CH Hautepierre
🇫🇷Strasbourg, France
Ch Du Pays Du Mont Blanc
🇫🇷Sallanches, France
Chg Salon de Provence
🇫🇷Salon de Provence, France
CH Tarbes
🇫🇷Tarbes, France
Ch Le Chesnay
🇫🇷Versailles, France
Chu Felix Guyon
🇫🇷Saint Denis, La Réunion, France
Ch St Esprit
🇫🇷Agen, France
CHU Angers
🇫🇷Angers, France
Ch General Aix En Provence -
🇫🇷Aix-en-Provence, France
CH d'ANGOULEME
🇫🇷Angoulème, France
Pringy - Ch D'Annecy
🇫🇷Annecy, France
CH Argenteuil
🇫🇷Argenteuil, France
Ch Armentieres
🇫🇷Armentières, France
CH Arpajon
🇫🇷Arpajon, France
Ch Auxerre
🇫🇷Auxerre, France
CH GENERAL Henri Duffaut
🇫🇷Avignon, France
CHU de BESANCON
🇫🇷Besançon, France
Hopital Femme Enfant
🇫🇷Caen, France
Ch de Pontoise
🇫🇷Cergy-Pontoise, France
Ch W. Morey
🇫🇷Chalon-sur-Saône, France
CH de CHAMBERY
🇫🇷Chambéry, France
Ch Hotel Dieu
🇫🇷Chartres, France
CHU Estaing
🇫🇷Clermont-Ferrand, France
Hopital Louis Mourrier
🇫🇷Colombes, France
Hopital Louis Pasteur
🇫🇷Colmar, France
CH Sud Francilien
🇫🇷Corbeil-Essonnes, France
Centre Hospitalier intercommunal de Creteil
🇫🇷Creteil, France
Hopital D'Enfants Chu Dijon
🇫🇷Dijon, France
CH Louviers Val de Reuil
🇫🇷Elbeuf, France
CH d'HYERES
🇫🇷Hyères, France
CH Gonesse
🇫🇷Gonesse, France
Ch de Marne La Vallee
🇫🇷Jossigny, France
Chru de Grenoble
🇫🇷La Tronche, France
CHGénéral du HAVRE
🇫🇷Le Havre, France
Hopital Jeanne de Flandre
🇫🇷Lille, France
Hopital Roger Salengro - Lille
🇫🇷Lille, France
Hopital Saint Vincent de Paul
🇫🇷Lille, France
Ch de Longjumeau
🇫🇷Longjumeau, France
Lorient - Ch de Bretagne Sud
🇫🇷Lorient, France
Hopital Femme Mere Enfant-Bron
🇫🇷Lyon, France
Hopital Nord Enfants
🇫🇷Marseille, France
Hopital de Mantes
🇫🇷Mantes-la-Jolie, France
Hopital de Meaux
🇫🇷Meaux, France
Ch de Melun
🇫🇷Meulin, France
Chu Rouen
🇫🇷Rouen, France
Hopital Charles-Nicolle
🇫🇷Rouen, France
Hôpital Nord Franche-Comté
🇫🇷Trévenans, France
Ch Bretagne Atlantique
🇫🇷Vannes, France
CH Jean Monnet
🇫🇷Épinal, France
Ch de Dax
🇫🇷Dax, France
CHU Nimes Caremeau
🇫🇷Nîmes, France
QUIMPER - CH de Cornouaille
🇫🇷Quimper, France
RANG du FLIERS - C.H.A.M.
🇫🇷RANG du FLIERS, France
Hopital Américain CHU REIMS
🇫🇷Reims, France
CH RODEZ
🇫🇷Rodez, France
CH de ROMANS
🇫🇷Romans-sur-Isère, France
Chu St Etienne
🇫🇷Saint Etienne, France
CH de TROYES
🇫🇷Troyes, France
CHU Toulouse-hôpital des Enfants
🇫🇷Toulouse, France
Ch de Saint Denis
🇫🇷Saint-Denis, France
Hôpital Gatien De Clocheville
🇫🇷Tours, France
Hopital de Villeneuve Saint Georges
🇫🇷Villeneuve-Saint-Georges, France