Covid-19 Pediatric Observatory
- Conditions
- COVID-19
- Registration Number
- NCT04336956
- Lead Sponsor
- Centre Hospitalier Intercommunal Creteil
- Brief Summary
In early December 2019, cases of pneumonia of unknown origin were reported in Wuhan, Hubei Province in the People's Republic of China. The disease spreads rapidly and the number of sick people is increasing. On January 3, 2020 a new virus of the coronavirus family is identified in samples of bronchoalveolar lavage fluid from a patient in Wuhan and subsequently confirmed as the cause of these pneumonias. On 7 January 2020, the World Health Organization (WHO) designated it as the new coronavirus 2019 (i.e. 2019-nCoV). On 11 February 2020, the WHO designated the disease associated with 2019-nCoV as coronavirus 2019 disease (COVID-19). On 12 March, WHO announced that the COVID-19 outbreak is a pandemic.
As of March 24, 2020, more than 375,000 cases of COVID-19 had been diagnosed with more than 16,000 deaths attributed to this virus. (Ref WHO https://www.who.int/emergencies/diseases/novel-coronavirus-2019 ).
In France, the number of cases rose from 105 cases at the end of February to 19615 confirmed cases on March 24. (Source Public Health France). Most of the cases are adults. However, children are not completely spared and serious cases have been described. These severe cases can be respiratory or extra-respiratory (e.g. myocarditis). We also know that pediatric and adult cases differ in terms of clinical, biological and imaging findings, particularly chest CT scans. However, the description of paediatric pictures, especially severe forms and the involvement of children suffering from co-morbidities, remains poorly reported. Finally, the risk factors for serious cases in children remain largely unknown.
This observatory aim to describe the clinical phenotypes of hospitalized pediatric patients with Covid19 in France, according to age groups. Moreover for a subgroup of patients, informations regarding the long covid will be reported.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 5000
- Children < 18 years old
- Admitted in French pediatric wards
- With a confirmed COVID-19 infection. ( on Nasal and pharyngeal swab specimens or blood samples tested positive for 2019-nCoV nucleic acid using real-time reverse-transcriptase polymerase-chain-reaction (RT- PCR) assay; or on typical chest CT signs
- Expressed refusal to participate
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percentage of children with severe or critical form. Day 14
- Secondary Outcome Measures
Name Time Method Pulmonary echography Day 14 requiring intensive care support or not
Clinical symptoms of children day 14 requiring intensive care support or not
CT chest of children at admission requiring intensive care support or not
Biological results of children day 14 requiring intensive care support or not
nasopharynx SARScov2 PCR at admission number of hospital days up to 12months days
nasopharynx multiplex PCR at admission if available
nasopharynx sarscov2 load at day 7 if available
Evaluation of long covid up to 12months Percentage of children requiring intensive care support at day 14
Trial Locations
- Locations (76)
Chu Felix Guyon
🇫🇷Saint Denis, La Réunion, France
Ch St Esprit
🇫🇷Agen, France
Ch General Aix En Provence -
🇫🇷Aix-en-Provence, France
CHU Angers
🇫🇷Angers, France
CH d'ANGOULEME
🇫🇷Angoulème, France
Pringy - Ch D'Annecy
🇫🇷Annecy, France
CH Argenteuil
🇫🇷Argenteuil, France
Ch Armentieres
🇫🇷Armentières, France
CH Arpajon
🇫🇷Arpajon, France
Ch Auxerre
🇫🇷Auxerre, France
Scroll for more (66 remaining)Chu Felix Guyon🇫🇷Saint Denis, La Réunion, FranceBenjamin AzemarContact