The effect of Folic acid supplementation in patients with type 2 diabetes
Phase 3
- Conditions
- Type 2 diabetes.non-Insulin-dependent diabetes mellitus
- Registration Number
- IRCT138811033140N1
- Lead Sponsor
- Tabriz university of medical sciences & Nutrition research committee
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 70
Inclusion Criteria
having the type 2 diabetes -voluntary consent for participation in the study -use of metformin at least 1500mg/day for >6month.
Exclusion criteria: -use of multivitamin-mineral supplements at least 6month before the study -smoking, alcohol abuse -treatment with insulin -having the hepatic, renal failure, cardiovascular, celiac, gastrointestinal, rheumatic, endocrine, thyroid disorders -leukemia -abnormalities in the enzymes that metabolize the hemocysteine –use of corticosteroids, anticonvulsants, isoniazid
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of antioxidant indices. Timepoint: 8weeks. Method of measurement: Assessments of changes in MDA and TAC.;FBS, insulin resistance, HbA1C, creatinine, lipid profiles. Timepoint: 8weeks. Method of measurement: laboratory.;Serum hemocysteine, folic acid and B12. Timepoint: 8weeks. Method of measurement: laboratory.
- Secondary Outcome Measures
Name Time Method Blood pressure. Timepoint: 8weeks after the supplementation. Method of measurement: Sphygmometer.;Body Mass Index. Timepoint: 8 weeks after the supplementation. Method of measurement: Weight(Kg)/height(m2).