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Clinical Trials/NL-OMON36671
NL-OMON36671
Withdrawn
N/A

Spontaneous breathing and work-of-breathing in mechanically ventilated children - Pediatric Work of Breathing

niversitair Medisch Centrum Groningen0 sites15 target enrollmentTBD
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Conditionsdistribution of ventilationLung mechanicswork of breathing10038716

Overview

Phase
N/A
Intervention
Not specified
Conditions
distribution of ventilation
Sponsor
niversitair Medisch Centrum Groningen
Enrollment
15
Status
Withdrawn
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Interventional

Investigators

Eligibility Criteria

Inclusion Criteria

  • •\*mechanical ventilation for at least 24hours
  • •\*weight\> 3kg
  • •\*able to initiate and maintain spontaneous breathing
  • •\*stable ventilator settings, defined by the absence of need for increase of inspiratory pressures or positive end\-expiratory pressure, and a FiO2 \< 0\.4 for at least 6 hours prior to enrollment
  • •\*stable haemodynamics, defined by the absence of need for increase in vaso\-active drugs and/or fluid challenges at least 6 hours prior to enrolment
  • •\*leakage around the endotracheal tube less then 5%, defined by the ratio of the expiratory tidal volume both to the inspiratory tidal volume measured by the ventilator

Exclusion Criteria

  • •\*mechanical ventilation less than 24hours
  • •\*unstable ventilator settings, defined by the need for increase of inspiratory pressures or positive end\-expiratory pressure, and a FiO2 \> 0\.6 within 6 hours prior to enrolment
  • •\*unstable haemodynamics, defined by the need for increase in vaso\-ative drugs and/or fluid challenges within 6 hours prior to enrolment
  • •\*leakage around the endotracheal tube \> 5%
  • •\*admitted to the neonatal intensive care unit
  • •\*premature birth with gestational age corrected for age less than 40 weeks
  • •\*congenital or acquired neuromuscular disorders
  • •\*congenital or acquired central nervous system disorders with depressed respiratory drive
  • •\*congenital or acquired damage to the phrenic nerve
  • •\*congenital or acquired paralysis of the diaphragm

Outcomes

Primary Outcomes

Not specified

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