Spontaneous breathing and work-of-breathing in mechanically ventilated children - Pediatric Work of Breathing

niversitair Medisch Centrum Groningen0 个研究点目标入组 15 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•*mechanical ventilation for at least 24hours
•*weight> 3kg
•*able to initiate and maintain spontaneous breathing
•*stable ventilator settings, defined by the absence of need for increase of inspiratory pressures or positive end-expiratory pressure, and a FiO2 < 0.4 for at least 6 hours prior to enrollment
•*stable haemodynamics, defined by the absence of need for increase in vaso-active drugs and/or fluid challenges at least 6 hours prior to enrolment
•*leakage around the endotracheal tube less then 5%, defined by the ratio of the expiratory tidal volume both to the inspiratory tidal volume measured by the ventilator

•*mechanical ventilation less than 24hours
•*unstable ventilator settings, defined by the need for increase of inspiratory pressures or positive end-expiratory pressure, and a FiO2 > 0.6 within 6 hours prior to enrolment
•*unstable haemodynamics, defined by the need for increase in vaso-ative drugs and/or fluid challenges within 6 hours prior to enrolment
•*leakage around the endotracheal tube > 5%
•*admitted to the neonatal intensive care unit
•*premature birth with gestational age corrected for age less than 40 weeks
•*congenital or acquired neuromuscular disorders
•*congenital or acquired central nervous system disorders with depressed respiratory drive
•*congenital or acquired damage to the phrenic nerve
•*congenital or acquired paralysis of the diaphragm
•*use of neuromuscular blockade prior to enrolment
•*uncorrected congenital heart disorder
•*chronic lung disease

发起方