OPTimal IMAging strategy in patients suspected of non-traumatic Pulmonary disease at the ED: Chest X-ray or CTThe OPTIMACT trial
- Conditions
- dyspnoea, chest pain, cough, non-traumatic pulmonary disease, pneumoniabenauwdheid, pijn op de borst, hoesten, niet-traumatische longziekte, longontsteking
- Registration Number
- NL-OMON26615
- Lead Sponsor
- Academic Medical Centre, Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 1500
Inclusion Criteria
> 18 years,
• presenting at the Emergency Department with a suspicion of non-traumatic pulmonary disease: complaints of: dyspnoea, fever, chest pain or cough.
Exclusion Criteria
incapacitated patients,
• pregnant patients,
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome is a correct diagnosis at Emergency Department discharge (including use of other diagnostic measures if indicated), as confirmed by an independent adjudication committee at day 28.To evaluate the effects, in terms of patient-related health outcomes and costs, of replacing chest X-ray by ULD chest CT in the diagnostic work-up of patients suspected of non-traumatic pulmonary disease at the ED.
- Secondary Outcome Measures
Name Time Method To evaluate whether the replacement of chest X-ray by ultra-low-dose chest CT (ULD chest CT) in the diagnostic work-up of patients suspected of non-traumatic pulmonary disease at the Emergency Department leads to more accurate diagnoses and more timely treatment.<br>To evaluate for patients with clinically suspected community-acquired pneumonia (CAP),<br>- the diagnostic accuracy and clinical impact of performing ULD chest CT as compared to conventional chest X-ray.<br>- the accuracy of CT versus conventional X-ray to predict the etiology of the pneumonia.<br>- the value of new and previously described (molecular) biomarkers for the diagnosis and etiology of CAP.