Transcranial direct current stimulation and exposure and response prevention for treatment resistant obsessive-compulsive disorder: A case series

Curtin University Western Australia0 sites7 target enrollmentJanuary 18, 2021

Overview

No summary available.

Registry

who.int

Start Date

January 18, 2021

End Date

February 24, 2023

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Sponsor

Curtin University Western Australia

•A clinical diagnosis of DSM\-5 OCD using the MINI International Neuropsychiatric Interview.
•Treatment Refractory, defined as a Yale\-Brown Obsessive Compulsive Scale total score of \> 16 (moderate to extreme) after two failed pharmacological treatments for OCD, and unsuccessful cognitive behaviour therapy with exposure and response prevention.

•1\. Participants with a recent history of brain surgery, neurological condition associated with brain abnormalities (e.g., traumatic brain injury; recent stroke, tumour), implanted cranial devices, hearing aids (unless they can be removed), active skin lesions on the scalp.
•2\. History of migraine, epilepsy, seizures, unstable medical and/or psychiatric conditions; history of psychosis or bipolar disorder; high suicide/self\-harm risk.
•3\. Current or past (within the last 1\-month) use of benzodiazepines, anticonvulsants, Lithium Carbonate, psychostimulants, dextromethorphan and pseudoephedrine; recreational drug use.
•4\. Currently undergoing ERP therapy for OCD; any neuromodulation therapy (e.g., ECT, transcranial magnetic stimulation, tDCS) within the last 3\-months.
•5\. Participants who have initiated or changed SSRI/SRI dose in the last 12 weeks.