The effectiveness of an integrated approach of transcranial direct current stimulation and exposure and response prevention for treatment refractory obsessive-compulsive disorder: A case series
- Conditions
- Obsessive-Compulsive DisorderAnxietyDepressionMental Health - Other mental health disordersMental Health - AnxietyMental Health - Depression
- Registration Number
- ACTRN12621000035820
- Lead Sponsor
- Curtin University Western Australia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 7
A clinical diagnosis of DSM-5 OCD using the MINI International Neuropsychiatric Interview.
Treatment Refractory, defined as a Yale-Brown Obsessive Compulsive Scale total score of > 16 (moderate to extreme) after two failed pharmacological treatments for OCD, and unsuccessful cognitive behaviour therapy with exposure and response prevention.
1. Participants with a recent history of brain surgery, neurological condition associated with brain abnormalities (e.g., traumatic brain injury; recent stroke, tumour), implanted cranial devices, hearing aids (unless they can be removed), active skin lesions on the scalp.
2. History of migraine, epilepsy, seizures, unstable medical and/or psychiatric conditions; history of psychosis or bipolar disorder; high suicide/self-harm risk.
3. Current or past (within the last 1-month) use of benzodiazepines, anticonvulsants, Lithium Carbonate, psychostimulants, dextromethorphan and pseudoephedrine; recreational drug use.
4. Currently undergoing ERP therapy for OCD; any neuromodulation therapy (e.g., ECT, transcranial magnetic stimulation, tDCS) within the last 3-months.
5. Participants who have initiated or changed SSRI/SRI dose in the last 12 weeks.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method