Bleaching Effect of Strawberry Extract Versus Hydrogen Peroxide in Patients With Extrinsic Staining

Not Applicable

Not yet recruiting

• Conditions: Bleaching Effect and Postoperative Sensitivity of Strawberry Extract
• Interventions: Other: strawberry extract.

• Registration Number: NCT06287060
• Lead Sponsor: Cairo University

Brief Summary

with limited evidence based information in literature about using Strawberry extract for teeth bleaching in patients with extrinsic staining , it is beneficial to evaluate this new material using a randomized controlled clinical trial to test the null hypothesis that this extract will have the same effect as Hydrogen peroxide regarding the bleaching effect and hypersensitivity.

Detailed Description

The whitening effect of strawberry is due to the presence of malic acid, which acts as a natural astringent to remove surface discoloration. The ellagic acid content in strawberry is ranging from 0.43 to 4.64 mg/g dry weight. The more amount of ellagic acid will produce more potential OH clusters as a powerful oxidizer thus make the more effective bleaching process. Ellagic acid releases the OH and H radicals which will react with the tooth enamel organic molecules and disrupt the electron conjugation, as well as changing the energy absorption in the tooth enamel organic molecules to form smaller organic molecules with a lighter color. Ellagic acid has an OH cluster, not COOH cluster like any other acids. The electronegativity of the OH group will be easier to break and react with the organic molecules of tooth enamel.

Study Timeline

• Status Verified: 2024-02
• Study First Submitted: 2024-02-23
• Study First Submitted QC: 2024-02-23
• Last Update Submitted: 2024-02-23
• Study First Posted: 2024-02-29
• Last Update Posted: 2024-02-29
• Study Start: 2024-07
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Participant inclusion criteria:

1. At least 18 years old.
2. Good general and oral health.
3. six present maxillary anterior teeth.

Tooth inclusion criteria:

1. yellowing of teeth due to age.

2. stains due to coffee or tea.

3. light tetracycline stain.

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Exclusion Criteria

participant exclusion criteria:

1. patients undergoing radiotherapy or chemotherapy.
2. Pregnant females or breast feeders.
3. Bruxism and patients who reported tooth sensitivity.

Tooth exclusion criteria:

1. Hypoplastic enamel.
2. carious lesion.
3. sensitive recession area or sensitive tooth.
4. Amalgam staining.
5. Non vital tooth.
6. Discolration due to pulp trauma or necrosis.
7. presence of non carious cervical lesion.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
patients with extrinsic staining will be treated with strawberry extract.	strawberry extract.	-
patients with extrinsic staining will be treated with Hydrogen peroxide bleaching agent.	strawberry extract.	-

Primary Outcome Measures

Name	Time	Method
Bleaching effect of strawberry extract versus Hydrogen peroxide.	immediately , one week and one month after application.	objective assessment for the bleaching effect by spectrophotometer.

Secondary Outcome Measures

Name	Time	Method
post operative sensitivity.	immediately after bleaching agent removal , 24 hours after application.	Tooth sensitivity is scored according to the VRS verbal Rating scale, where 0=none, 1=mild, 2=moderate, 3=considerable, and 4=severe