Fluid restriction for term infants with hypoxic- ischaemic encephalopathy following perinatal asphyxia-a randomized controlled trial

Perinatal asphyxia and associated hypoxic ischaemic encephalopathy is an importnat cause of perinatally acquired brain damage in term infants.the rationale of fluid restriction in perinatal asphyxia is to avoid fluid overload and exacerbation of cerebral oedema.Restriction of fluid intake in cases of perinatal asphyxia is being practiced with experience in children and adults and animal experiments.Hence quantitative recommendation for fluid restriction cannot be obtained from above studies. We aim to study the effct of fluid restriction in term infants with perinatal asphyxia on neurological outcomes.Primary outcomes to be measured are neonatal mortality or severe neurodevelopmental disability at discharge.the secondary outcomes to be measured include electrolyte imbalance,oliguria,abnormal renal function,seizures and CT/MRI findings consistent with asphyxia.This is a randomized controlled trial to be completed  over a period of 2 years with 210 study participants with perinatal asphyxia.