Trial of alpha-interferon in chronic myeloid leukaemia and a comparison of busulphan and hydroxyurea for induction and maintenance
Not Applicable
Completed
- Conditions
- eukaemia (chronic)Cancer
- Registration Number
- ISRCTN46123985
- Lead Sponsor
- Medical Research Council (MRC) (UK)
- Brief Summary
1995 results in: https://www.ncbi.nlm.nih.gov/pubmed/7760609 (added 15/11/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 587
Inclusion Criteria
1. Aged over 75 years with either Ph positive or Ph negative chronic myeloid leukaemia in chronic phase. Patients over 75 years or patients unwilling to accept alpha-interferon, may be randomised to busulphan or hydroxyurea, but not interferon or no interferon
2. Adequate renal function
3. No severe concurrent hepatic, renal, cardiovascular, organic brain disease or psychiatric illness
4. Patients with established blast cell crisis or extramedullary granulocytic sarcomas are to be excluded
5. Patients with accelerated phase or platelet count below that specified in the protocol are not eligible
Exclusion Criteria
Not provided at time of registration.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ot provided at time of registration.
- Secondary Outcome Measures
Name Time Method ot provided at time of registration.