Bedside Tissue Oxygenation Monitoring With Noninvasive Jugular Venous Oximetry
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Oxygen Consumption
- Sponsor
- University of Wisconsin, Madison
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Accuracy of digital pulse oximetry
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The goal of this observational study is to find out if researchers can measure oxygen consumption in the body without having to draw blood from lines in arteries and central veins.
Participants will undergo measurements of arterial blood oxygen saturation using both finger and neck pulse oximeters.
Detailed Description
TOUCAN-1 is a study to estimate the accuracy and precision of pulse oximetry as a noninvasive tool for oxygen consumption measurement. Researchers will use a pair of commercially-available, noninvasive pulse oximeters to estimate the oxygen saturation of blood in the internal jugular vein, and compare it to the directly measured oxygen saturation in sampled jugular blood. Researchers will then measure the arterial oxygen saturation in a finger, and compare it to the directly measured oxygen saturation in sampled radial arterial blood.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Inpatient at the University of Wisconsin University Hospital
- •Has an internal jugular venous central line
- •Has a radial arterial line
Exclusion Criteria
- •Currently receiving extracorporeal membrane oxygenation (ECMO)
- •Currently receiving continuous renal replacement therapy (CRRT/CVVH)
- •All usable lumens of the participant's jugular catheter are in use, and interruption of any medical or therapy through any lumen would, in the view of the primary care team, compromise the participant's care.
- •Jugular venous catheter is not functional or position is not confirmed by radiography
- •Arterial cannula is not functional
- •Known history of sickle cell anemia or other hemoglobinopathy
- •Therapy with any of the following medications:
- •Nitroprusside
- •Hydroxocobalamin
- •Indocyanine green
Outcomes
Primary Outcomes
Accuracy of digital pulse oximetry
Time Frame: Through study completion, approximately 20 minutes
Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry
Accuracy of jugular pulse oximetry
Time Frame: Through study completion, approximately 20 minutes
Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry