Tissue Oxygen Use With Combined Arteriovenous Noninvasive Oximetry

Completed

• Conditions: Oxygen Consumption
• Interventions: Device: Finger pulse oximetry probe; Device: Transreflectance oximetry probe

• Registration Number: NCT06072755
• Lead Sponsor: University of Wisconsin, Madison

Brief Summary

The goal of this observational study is to find out if researchers can measure oxygen consumption in the body without having to draw blood from lines in arteries and central veins.

Participants will undergo measurements of arterial blood oxygen saturation using both finger and neck pulse oximeters.

Detailed Description

TOUCAN-1 is a study to estimate the accuracy and precision of pulse oximetry as a noninvasive tool for oxygen consumption measurement. Researchers will use a pair of commercially-available, noninvasive pulse oximeters to estimate the oxygen saturation of blood in the internal jugular vein, and compare it to the directly measured oxygen saturation in sampled jugular blood. Researchers will then measure the arterial oxygen saturation in a finger, and compare it to the directly measured oxygen saturation in sampled radial arterial blood.

Study Timeline

• Study First Submitted: 2023-10-02
• Study First Submitted QC: 2023-10-02
• Study First Posted: 2023-10-10
• Study Start: 2024-01-11
• Primary Completion: 2024-07-25
• Study Completion: 2024-07-25
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-21
• Last Update Posted: 2024-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Inpatient at the University of Wisconsin University Hospital
• Has an internal jugular venous central line
• Has a radial arterial line

Exclusion Criteria

• Currently receiving extracorporeal membrane oxygenation (ECMO)

• Currently receiving continuous renal replacement therapy (CRRT/CVVH)

• All usable lumens of the participant's jugular catheter are in use, and interruption of any medical or therapy through any lumen would, in the view of the primary care team, compromise the participant's care.

• Jugular venous catheter is not functional or position is not confirmed by radiography

• Arterial cannula is not functional

• Known history of sickle cell anemia or other hemoglobinopathy

• Therapy with any of the following medications:

  • Nitroprusside
  • Hydroxocobalamin
  • Indocyanine green
  • Norepinephrine
  • Vasopressin
  • Epinephrine
  • Any other medication or therapy that, in the judgement of the study investigators, may affect the accuracy and precision of the noninvasive oximetry results

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Critically ill adults	Transreflectance oximetry probe	Inpatient adults who require internal jugular venous central line and radial arterial line
Critically ill adults	Finger pulse oximetry probe	Inpatient adults who require internal jugular venous central line and radial arterial line

Primary Outcome Measures

Name	Time	Method
Accuracy of digital pulse oximetry	Through study completion, approximately 20 minutes	Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry
Accuracy of jugular pulse oximetry	Through study completion, approximately 20 minutes	Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry

Trial Locations

Locations (1)

University of Wisconsin; 🇺🇸 Madison, Wisconsin, United States