A randomized, double blind study on the effects of Continuous Intravenous Magnesium on Features of Central Sensitisation in CRPS1 patients.

VU University Medical center, Department of Anesthesiology.0 sites72 target enrollmentTBD

ConditionsCRPS1

Overview

Phase: N/A
Intervention: Not specified
Conditions: CRPS1
Sponsor: VU University Medical center, Department of Anesthesiology.
Enrollment: 72
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

2 years ago

Study Type

Interventional

Investigators

Sponsor

VU University Medical center, Department of Anesthesiology.

Eligibility Criteria

Inclusion Criteria

•1\. Diagnostic criteria for CRPS1 according to the IASP (1\):
•a. Presence of an initiating noxious event or cause for immobilisation;
•b. Continuing pain, allodynia or hyperalgesia, with which the pain is disproportioned to any inciting event and is not limited to the area of an individual peripheral nerve;
•c. Evidence at any time of oedema. Skin blood flow abnormality, or abnormal sudomotor activity in the painful area since the inciting event;
•d. Conditions which could otherwise account for the level of pain and dysfunction should be excluded;
•Note: criteria b\-d have to be met.
•2\. A VAS\-spontaneous pain score of 5 cm or higher;
•3\. Patients should be between 18 \-70 years old;
•4\. CRPS1 in one extremity;
•5\. First time experience of patient with CRPS1;

Exclusion Criteria

•1\. Not being able to give informed consent;
•2\. Another (2nd) chronic pain syndrome, interfering with pain ratings;
•3\. Another syndrome interfering with functional tests;
•4\. CRPS1 in both hands or feet;
•5\. Patient has experienced CRPS1 before;
•6\. Known kidney and/or severe liver disease;
•7\. Known nerve damage in the affected area;
•8\. Active infection;
•9\. Mental retardation;
•10\..Psychiatric abnormality ;

Outcomes

Primary Outcomes

Not specified

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