Hydrogen Inhalation for Health and Exercise Performance

Not Applicable

Completed

• Conditions: Exercise Performance
• Interventions: Other: Hydrogen; Other: Placebo

• Registration Number: NCT03846141
• Lead Sponsor: University of Novi Sad, Faculty of Sport and Physical Education

Brief Summary

In this randomized double-blind, placebo-controlled, crossover pilot trial, we evaluated the effects of 7-day H2 inhalation on exercise performance outcomes and serum hormonal and inflammation profiles in a cohort of young men and women.

Detailed Description

All participants were allocated to receive either gaseous hydrogen (4%) or placebo (room air) by 20-min once-per-day inhalation for 7 days, with wash-out period of 7 days to prevent the residual effects of interventions across study periods. The primary treatment outcome was the change in running time-to-exhaustion from baseline to day 7. Additionally, assessment of other exercise performance endpoints and clinical chemistry biomarkers were performed at baseline and after 7 days after each intervention.

Study Timeline

• Study Start: 2018-01-15
• Primary Completion: 2018-06-15
• Study Completion: 2018-09-15
• Status Verified: 2019-02
• Study First Submitted: 2019-02-17
• Study First Submitted QC: 2019-02-17
• Last Update Submitted: 2019-02-18
• Study First Posted: 2019-02-19
• Last Update Posted: 2019-02-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Age ≥ 18 -35 years Body mass index 20 - 25 kg/m2 Free of major diseases Physically active Must be able to give written informed consent

Exclusion Criteria

Use of any dietary supplements within 4 weeks before study commences Abnormal values for lab clinical chemistry (> 2 SD)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Hydrogen	Hydrogen	Hydrogen (4%) for inhalation
Placebo	Placebo	Room air for inhalation

Primary Outcome Measures

Name	Time	Method
Change in exercise performance	Change from baseline running time-to-exhaustion at 7 days	Running time-to-exhaustion

Secondary Outcome Measures

Name	Time	Method
Change in exercise performance	Change from baseline maximal voluntary isometric strength at 7 days	Maximal voluntary isometric strength
Change in clinical chemistry biomarker	Change from baseline serum ghrelin at 7 days	Ghrelin

Trial Locations

Locations (1)

FSPE Applied Bioenergetics Lab; 🇷🇸 Novi Sad, Vojvodina, Serbia