ongitudinal study for Cognitive function and Brain structural changes associated with Ablation-therapy for Atrial fibrillatio

Not Applicable

• Conditions: Atrial fibrillation

• Registration Number: JPRN-UMIN000023007
• Lead Sponsor: Tohoku University, Institute of Development, Aging and cancer

Brief Summary

Cognitive-psychological function was improved, and rCBF was significantly increased in the left posterior cingulate cortex (PCC) (p=0.013), whereas decreased cortical thickness was found in the left posterior insular cortex (p =0.023).

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-10
• Study Completion: 2020-03-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Not provided

Exclusion Criteria

(1)patients with past history of neuro-psychological disorders and significant organic diseases (2)Patients with hemorrhagic symptoms (3)Patients with coagulation defect associated with hepatic disease (4)Patients with renal failure (5)Patients with difficulty in obtaining written informed consent (6)Patients in whom physician-in-charge decides unsuitable for this study (7)Patients with difficulty in evaluating brain MRI:Patients undergoing Pacemaker-implantation, coronary artery stenting and other metal device implantation or patients with claustrophobia (8)Patients with pregnancy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
(1) Cognitive function, (2)Gray matter volume, (3)Cerebral blood flow (CBF) Comparison those parameters between before and after 6 months following Ablation therapy.