Hyperoxia Before and After Cardiac Arrest and Myocardial Damage, a Retrospective Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiac Arrest
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
- Enrollment
- 163
- Locations
- 1
- Primary Endpoint
- Peak troponin within 30 days after cardiac arrest
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Several studies show how patients with hyperoxia after cardiac arrest has increased mortality, but the association of hyperoxia before cardiac arrest and myocardial damage has never been investigated. Neither has the association between hyperoxia after cardiac arrest and myocardial injury.
Our research hypothesis is that hyperoxia before cardiac arrest aggravates myocardial damage, secondly we wish to analyze the association between hyperoxia after cardiac arrest and myocardial injury.
The exposure variables is oxygenation within 48 hours before and 48 hours after cardiac arrest, our primary outcome is myocardial damage and will be measured as peak troponin within 30 days after cardiac arrest.
Investigators
Kathrine Schmidt Groenbek
Research Assistant, Bispebjerg Hospital.
University Hospital Bispebjerg and Frederiksberg
Eligibility Criteria
Inclusion Criteria
- •18 years or older
- •With a record of ICD-10 diagnosis of cardiac arrest in 2014, admitted to a hospital in the Capital Region of Denmark.
- •First recorded cardiac arrest in 2014
- •Admitted to ICU
- •Serum troponin measured within 7 days after cardiac arrest
Exclusion Criteria
- •Out of hospital cardiac arrest, OHCA
- •In of hospital cardiac arrest, IHCA, but with no registered saturation before cardiac arrest.
Outcomes
Primary Outcomes
Peak troponin within 30 days after cardiac arrest
Time Frame: 30 days
Troponin measurements on patients after cardiac arrest.
Secondary Outcomes
- Troponin area under the curve within 3 days after cardiac arrest(3 days)
- 30-day and 1-year mortality(Up to 1 year.)
- Length of ICU stay after cardiac arrest(through study completion,on average of 4-8 weeks.)
- Length of hospital stay after cardiac arrest(through study completion,on average of 4-8 weeks.)