Hyperoxia Before and After Cardiac Arrest and Myocardial Damage

Completed

• Conditions: Cardiac Arrest

• Registration Number: NCT03571074
• Lead Sponsor: University Hospital Bispebjerg and Frederiksberg

Brief Summary

Several studies show how patients with hyperoxia after cardiac arrest has increased mortality, but the association of hyperoxia before cardiac arrest and myocardial damage has never been investigated. Neither has the association between hyperoxia after cardiac arrest and myocardial injury.

Our research hypothesis is that hyperoxia before cardiac arrest aggravates myocardial damage, secondly we wish to analyze the association between hyperoxia after cardiac arrest and myocardial injury.

The exposure variables is oxygenation within 48 hours before and 48 hours after cardiac arrest, our primary outcome is myocardial damage and will be measured as peak troponin within 30 days after cardiac arrest.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-05-30
• Study First Submitted: 2018-06-04
• Study First Submitted QC: 2018-06-17
• Study First Posted: 2018-06-27
• Primary Completion: 2018-08-10
• Study Completion: 2018-09-30
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-20
• Last Update Posted: 2018-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 163

Inclusion Criteria

• 18 years or older
• With a record of ICD-10 diagnosis of cardiac arrest in 2014, admitted to a hospital in the Capital Region of Denmark.
• First recorded cardiac arrest in 2014
• Admitted to ICU
• Serum troponin measured within 7 days after cardiac arrest

Exclusion Criteria

• Out of hospital cardiac arrest, OHCA
• In of hospital cardiac arrest, IHCA, but with no registered saturation before cardiac arrest.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak troponin within 30 days after cardiac arrest	30 days	Troponin measurements on patients after cardiac arrest.

Secondary Outcome Measures

Name	Time	Method
Troponin area under the curve within 3 days after cardiac arrest	3 days
30-day and 1-year mortality	Up to 1 year.
Length of ICU stay after cardiac arrest	through study completion,on average of 4-8 weeks.
Length of hospital stay after cardiac arrest	through study completion,on average of 4-8 weeks.

Trial Locations

Locations (1)

Bispebjerg Hospital; 🇩🇰 Copenhagen, Denmark