Hyperoxia Before and After Cardiac Arrest and Myocardial Damage, a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 163
- 试验地点
- 1
- 主要终点
- Peak troponin within 30 days after cardiac arrest
研究概览
简要总结
Several studies show how patients with hyperoxia after cardiac arrest has increased mortality, but the association of hyperoxia before cardiac arrest and myocardial damage has never been investigated. Neither has the association between hyperoxia after cardiac arrest and myocardial injury.
Our research hypothesis is that hyperoxia before cardiac arrest aggravates myocardial damage, secondly we wish to analyze the association between hyperoxia after cardiac arrest and myocardial injury.
The exposure variables is oxygenation within 48 hours before and 48 hours after cardiac arrest, our primary outcome is myocardial damage and will be measured as peak troponin within 30 days after cardiac arrest.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years or older
- •With a record of ICD-10 diagnosis of cardiac arrest in 2014, admitted to a hospital in the Capital Region of Denmark.
- •First recorded cardiac arrest in 2014
- •Admitted to ICU
- •Serum troponin measured within 7 days after cardiac arrest
排除标准
- •Out of hospital cardiac arrest, OHCA
- •In of hospital cardiac arrest, IHCA, but with no registered saturation before cardiac arrest.
结局指标
主要结局
Peak troponin within 30 days after cardiac arrest
时间窗: 30 days
Troponin measurements on patients after cardiac arrest.
次要结局
- Troponin area under the curve within 3 days after cardiac arrest(3 days)
- 30-day and 1-year mortality(Up to 1 year.)
- Length of ICU stay after cardiac arrest(through study completion,on average of 4-8 weeks.)
- Length of hospital stay after cardiac arrest(through study completion,on average of 4-8 weeks.)
研究者
Kathrine Schmidt Groenbek
Research Assistant, Bispebjerg Hospital.
University Hospital Bispebjerg and Frederiksberg