Transient Receptor Potential Vanilloid One (TRPV1) Receptor Expression in Children With Retrosternal Pain

Completed

• Conditions: Gastrointestinal Symptoms; Esophagitis; Epigastric Pain; Retrosternal Pain

• Registration Number: NCT00677378
• Lead Sponsor: Medical College of Wisconsin

Brief Summary

We would like to evaluate the changes in nerve innervation and TRPV1 receptor expression along with microscopic changes associated with heart burn and abdominal pain

Detailed Description

Approximately 5% of children between 10-17 years of age report symptoms of heart burn, epigastric pain or regurgitation. This study will evaluate the changes in nerve innervation and TRPV1 receptor expression in children having upper endoscopy for evaluation of heart burn and abdominal pain.

Study Timeline

• Study Start: 2006-12
• Study First Submitted: 2008-05-09
• Study First Submitted QC: 2008-05-13
• Study First Posted: 2008-05-14
• Primary Completion: 2014-12
• Status Verified: 2015-10
• Study Completion: 2015-10
• Last Update Submitted: 2015-10-21
• Last Update Posted: 2015-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

• Retrosternal and/or epigastric pain and esophagitis
• Retrosternal and/or epigastric pain but no macroscopic or microscopic esophagitis
• Gastrointestinal symptoms such as diarrhea, regurgitation, rumination, vomiting, feeding aversion, non-organic failure to thrive, celiac disease with no macroscopic or microscopic esophageal inflammation

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To characterize the TRPV1 expression in the esophageal mucosa of children with esophagitis and to correlate the TRPV1 expression with severity of mucosal inflammation and microscopic changes.	5 years

Trial Locations

Locations (1)

Medical College of Wisconsin; 🇺🇸 Milwaukee, Wisconsin, United States