A Comparison of Telmisartan 80 mg + Hydrochlorothiazide 12.5 mg With Amlodipine 10 mg + Hydrochlorothiazide 12.5 mg in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension. A Prospective, Randomised, Open-label, Blinded End-point Evaluation. (ATHOS Study)

简要总结

主要结局

次要结局

• Proportion of patients achieving a target response in SBP(14 weeks)
• Proportion of patients achieving normal blood pressure(14 weeks)
• Change from baseline in trough seated SBP(14 weeks)
• Change from baseline in pulse pressure (PP) in the last six hours of the 24-hour dose period(week 8 and 14)
• Change from baseline in SBP in the last six hours of the 24-hour dose period (as measured by 24-hour ABPM).(8 weeks)
• Proportion of patients achieving SBP control(14 weeks)
• Change from baseline in patient HRQL as measured by the Psychological General Well-Being (PGWB) index.(week 8 and 14)
• Change from baseline in trough seated DBP(14 weeks)
• Change from baseline in DBP in the last six hours of the 24-hour dose period(week 8 and 14)
• Change from baseline SBP and DBP for other time intervals ( i.e. 24-hour mean, morning mean (06:00-11:59), daytime mean (06:00-21:59), and night-time mean (22:00-05:59))(week 8 and 14)
• Proportion of patients achieving high-normal blood pressure(14 weeks)
• Safety and tolerability of the combination of telmisartan 80 mg and HCTZ 12.5 mg compared with amlodipine 10 mg and HCTZ 12.5 mg(14 weeks)