Sensitive Periods in Human Flavor Learning
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 97
- 试验地点
- 2
- 主要终点
- Vegetable Flavor Acceptance [Infants' Intake]
研究概览
简要总结
The goals of the proposed research are to specify the timing and consequences of the sensitive period for flavor learning in infants who are being breastfed or formula fed. The investigators will conduct a randomized within- and between-subject study of women and their infants during a 15-month window.
详细描述
This is a randomized clinical trial on both breastfeeding and formula feeding infants to determine the effects of the timing of flavor experiences on subsequent food acceptance in both members of the dyad.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 2 Weeks 至 3 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy, term infants and their mothers
- •Infants 2 wks (+/- 2 wk of age)
- •Mothers and infants exclusively breastfeeding or exclusively feeding a cows-milk based formula
- •Mothers must be older than 18 years of age
排除标准
- •Infants who were preterm or have medical conditions that interfere with feeding or eating
- •Mothers who had gestational diabetes or are diagnosed with a major illness requiring treatment or surgery
- •Mothers who will be going back to work full-time before the infant is 4 months old
- •Mothers who are allergic to any vegetables
- •Subjects will not be excluded because of economic status, gender, race or ethnicity.
结局指标
主要结局
Vegetable Flavor Acceptance [Infants' Intake]
时间窗: 6- to 10-month-old weaned infants (3 separate test days )
Taste testing conducted on infants to determine acceptance of plain cereal, carrot-flavor cereal (exposed flavor for intervention groups) and broccoli-flavored cereal (novel flavor for all groups) after weaning, which occurred at \~ 8 months of age. Outcomes included intake (in grams).
Taste Liking Ratings of Vegetable Flavors [Mothers].
时间窗: Monthly, 0.5 to 4.5 months
Psychophysical testing conducted on mothers to rate their taste of carrot, beet, celery, mixed vegetable (exposed flavors for intervention groups) and apple juices using the hedonic gLMS (hedonic general labelled magnitude scale). Ratings on the scale range from -100 (strongest imaginable dislike) to 0 (neutral) to 100 (strongest imaginable like).
Vegetable Flavor Acceptance (Infants' Rate of Feeding)
时间窗: 6- to 10-month-old weaned infants (3 separate test days)
Taste testing conducted on infants to determine acceptance of plain cereal, carrot-flavor cereal (exposed flavor for intervention groups) and broccoli-flavored cereal (novel flavor for all groups) after weaning, which occurred at \~ 8 months of age. Outcomes included intake rate of feeding (grams per minute) .
次要结局
- Maternal Perceptions(6- to 10-month-old weaned infants (3 separate test days))
- Growth of Infants(Once a month from ages 0.5 - 4.5 months, 10.5 months)
研究者
Julie A. Mennella, PhD
Member and Director Emeritus
Monell Chemical Senses Center