Comparison of Gut Microbial Composition and Function in CRPS Patients vs. Healthy Individuals
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- CRPS
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- Gut microbiome composition
- Status
- Active, not recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this study is to investigate, for the first time, whether gut bacteria composition and function of patients with CRPS differ from those of healthy adults. Samples of stool, urine and blood will be collected from patients with CRPS and from healthy adults. The type and function of bacteria of CRPS patients will be analyzed and compared to those of healthy adults to test if potential differences could explain the mechanism/s involved with the development of CRPS.
Investigators
Dr. Yoram Shir
Director, the Alan Edwards Pain Management Unit
McGill University Health Centre/Research Institute of the McGill University Health Centre
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Gut microbiome composition
Time Frame: 1 day
Assessment of genomic composition of the gut bacteria by differential abundance analysis will be performed using 16S rRNA (Genome-Quebec)
Presence of stool microbiota-related metabolites affecting host physiology
Time Frame: 1 day
Concentration of bile acids and short-chain-fatty-acids through Metabolomics analysis (Metabolon, USA).
Secondary Outcomes
- Pittsburg Sleep Quality Index (PSQI) scores(1 day)
- Short-form health-questionnaire (SF12) score(1 day)
- Brief Pain Inventory (BPI) score(1 day)
- Patient Health Questionnaire (PHQ-9) score(1 day)