Comparison of Gut Microbial Composition and Function in CRPS Patients vs. Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Gut microbiome composition
研究概览
简要总结
The purpose of this study is to investigate, for the first time, whether gut bacteria composition and function of patients with CRPS differ from those of healthy adults. Samples of stool, urine and blood will be collected from patients with CRPS and from healthy adults. The type and function of bacteria of CRPS patients will be analyzed and compared to those of healthy adults to test if potential differences could explain the mechanism/s involved with the development of CRPS.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Gut microbiome composition
时间窗: 1 day
Assessment of genomic composition of the gut bacteria by differential abundance analysis will be performed using 16S rRNA (Genome-Quebec)
Presence of stool microbiota-related metabolites affecting host physiology
时间窗: 1 day
Concentration of bile acids and short-chain-fatty-acids through Metabolomics analysis (Metabolon, USA).
次要结局
- Pittsburg Sleep Quality Index (PSQI) scores(1 day)
- Short-form health-questionnaire (SF12) score(1 day)
- Brief Pain Inventory (BPI) score(1 day)
- Patient Health Questionnaire (PHQ-9) score(1 day)
研究者
Dr. Yoram Shir
Director, the Alan Edwards Pain Management Unit
McGill University Health Centre/Research Institute of the McGill University Health Centre