NCT00789841已完成不适用
Gastrointestinal Motility in Patients With Neuroendocrine Tumors-Effects of Sandostatin LAR
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Gastrointestinal transit time in NET patients
研究概览
简要总结
We will study the total gastrointestinal transit time (GITT), gastric emptying and small intestine motility in NET patients before and after treated with somatostatin analogues and compare these to healthy subjects. For this we will use radio-opaque markers and the newly developed Motility Tracking System (MTS).
Hypothesis: Patients with NET and carcinoid syndrome have decreased GITT, gastric emptying and small bowel transit time and an increase in phase III MMC activity compared to healthy subjects. Treatment with somatostatin analogues increase transit times and decrease phase III MMC activity and improves the clinical symptoms.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •NET confirmed by histology
- •Diarrhea, (at least 3 loose or watery bowel movements per day) as part of carcinoid syndrome.
- •Newly referred patients without previous somatostatin analogue treatment or
- •NET patients who are pausing somatostatin analogue treatment due to other treatment or examination.
排除标准
- •Subjects unable to understand the information
- •Severe diabetes with late complications or known metabolic disorder
- •Inflammatory bowel disease
- •Known clinically significant stenosis of the bowel
- •Bile acid malabsorption due to intestinal surgery
- •Small bowl bacterial overgrowth
结局指标
主要结局
Gastrointestinal transit time in NET patients
时间窗: End of the study
次要结局
- Gastric emptying in NET patients(End of the study)
- Small intestinal transit time(End of the study)
- Small intestinal velocity(End of the study)
- Changes in carcinoid symptoms and biomarkers(End of the study)
研究者
研究点 (1)
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