Multimodal Investigation of Neural Plasticity Induced by Non-invasive Brain Stimulation
Overview
- Phase
- N/A
- Intervention
- active tDCS
- Conditions
- Mild Cognitive Impairment
- Sponsor
- University of Michigan
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Changes in glutamate concentration (fMRS)
- Status
- Recruiting
- Last Updated
- last month
Overview
Brief Summary
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).
Detailed Description
The goal of this study is to learn important information about the effects of weak electrical stimulation (known as high-definition transcranial direct current stimulation or HD-tDCS) on brain functioning in those with mild cognitive impairment (MCI). The findings will help determine how stimulation affects brain's activity and metabolism (in particular, the neurotransmitter glutamate). Ultimately, this information may help develop new treatments for those with Alzheimer's disease. The study will use different forms of brain imaging to see whether stimulation changes how the brain responds during a memory task. Functional magnetic resonance spectroscopy (fMRS), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS) will be used. The study also uses cognitive tests and questionnaires.
Investigators
Alexandru Iordan
Assistant Professor of Psychiatry, Medical School
University of Michigan
Eligibility Criteria
Inclusion Criteria
- •Normal cognition for HC and diagnosis of Mild Cognitive Impairment (MCI) for MCI participants
- •Right-handedness
- •Magnetic resonance compatible, criteria that also apply for high definition transcranial direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants in the upper body or head)
Exclusion Criteria
- •History of other contributing neurological or medical conditions known to affect cognitive functioning
- •Significant mental illness
- •Sensory impairments that limit ability to participate
- •History of alcohol or drug abuse/dependence
Arms & Interventions
MCI active tDCS
3 milliAmp dose of HD-tDCS treatment for 20 minutes, for 1 session.
Intervention: active tDCS
HC sham tDCS
Sham (placebo) dose of HD-tDCS treatment for 20 minutes, for 1 session.
Intervention: sham tDCS
HC active tDCS
3 milliAmp dose of HD-tDCS treatment for 20 minutes, for 1 session.
Intervention: active tDCS
MCI sham tDCS
Sham (placebo) dose of HD-tDCS treatment for 20 minutes, for 1 session.
Intervention: sham tDCS
Outcomes
Primary Outcomes
Changes in glutamate concentration (fMRS)
Time Frame: average on 1 week
Analyses via fMRS using units of concentration
Changes in brain activation (fMRI)
Time Frame: average of 1 week
Analyses via fMRI using units of brain activation
Secondary Outcomes
- Changes in memory performance(average of 1 week)
- Changes in brain activation (fNIRS)(immediate, concurrent with tDCS)