Study on the clinical efficacy of Yiqi Huoxue Jiedu formula in the treatment of platinum resistant ovarian cancer based on the phenotypic changes of macrophages

Phase 1

Recruiting

• Conditions: ovarian cancer

• Registration Number: ITMCTR2100005211
• Lead Sponsor: Guang'anmen Hospital, Chinese Academy of traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients with primary epithelial ovarian cancer were diagnosed by surgical pathology;
2. Relapse within 6 months after the last platinum based chemotherapy withdrawal, or progress during chemotherapy;
3. The syndrome type of traditional Chinese medicine is Qi deficiency and blood stasis syndrome. The syndrome differentiation refers to the guiding principles for clinical research of new traditional Chinese medicine. The Qi deficiency syndrome and blood stasis syndrome are completed under the guidance of the chief physician of traditional Chinese medicine. Qi deficiency syndrome: it is necessary to differentiate between light tongue, light fat tongue, tooth marks on the edge of light tongue and two of shortness of breath, fatigue, spontaneous sweating, weak pulse or weak pulse; Blood stasis syndrome: facial ecchymosis, pain, precordial pain, limb numbness, hemiplegia, wrong skin nail, dark complexion, menstrual blood clot, dark tongue, ecchymosis, blue and purple sublingual vein. Syndrome differentiation can be achieved if there are 2 or more;
4. ECoG score: 0-1;
5. Estimated survival time >= 2 months;
6. Sign informed consent.

Exclusion Criteria

1. Previous history of other tumors;
2. those with infectious diseases or immune system diseases have not yet been controlled;
3. Recent use of immunosuppressants;
4. Suffering from serious heart, liver, kidney and hematopoietic diseases without control;
5. Accompanied by mental illness, severe neurological deficit (such as aphasia and agnosia) or unable to cooperate with the investigation due to other reasons;
6. Those who are allergic to the drugs in this prescription.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
M2;IL6;