REducing Sleep Apnoea for the PrEvention of Dementia (REShAPED): a multi-site feasibility randomised controlled trial

The University of Sydney0 sites180 target enrollmentSeptember 6, 2021

Overview

No summary available.

Registry

who.int

Start Date

September 6, 2021

End Date

TBD

Last Updated

3 years ago

Study Type

Interventional

Sex

All

Sponsor

•1\.Subjective cognitive decline (new onset cognitive decline within the last 5 years)
•2\.Able to provide informed written consent
•3\.Fluent English literacy
•4\.Adults aged between 50\-75 years
•5\.Mild – Severe OSA based on an average ODI equal to or greater to 10 with 3% oxygen desaturation determined by oximetry over two nights.

•1\.Previous or current CPAP or mandibular device or oxygen user or body position device user (within past 3 months)
•2\.People highly dependent on medical care
•3\.Previous diagnosis of dementia or MMSE less than 24
•4\.Previous major head injury or loss of consciousness equal to or greater than 30 minutes
•5\.Previous or current substance misuse or use of medicinal cannabis
•6\.Previous or current neurological disorder diagnosis (e.g. Parkinson’s, multiple sclerosis, epilepsy, stroke)
•7\.Psychiatric or developmental disorders (e.g. Schizophrenia, bipolar disorder, autism)
•8\.Current major depression diagnosis
•9\.Major sleep disorders (e.g. narcolepsy, severe restless legs syndrome, severe insomnia disorder unrelated to a sleep\-breathing disorder)
•10\.Shift workers