Pilot Study to Evaluate Fatigue and Fatigability Profiles and Their Impact on Walking and Balance in Patients With Charcot-Marie-Tooth Type 1A Disease Using a Global Approach in Comparison to Healthy Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Fatigability profile
研究概览
简要总结
Charcot-Marie-Tooth disease type 1A is the most common form of inherited neuropathy that causes peripheral nerve damage in all four limbs. In addition to the well-known distal motor and sensory symptoms, fatigue is one of the most common symptoms reported by patients. However, there is very little scientific data on this topic. Fatigue is associated with changes in mobility and quality of life. This study investigates the magnitude and impact of fatigue on patients' sensory-motor function and mobility (standing and walking). Fatigue is a complex phenomenon. It is therefore essential to assess all the factors that may be at the origin of this symptom (perceived fatigue and fatigability) using innovative and robust assessment methods.
These methods are based on quantitative non-invasive neurophysiologic measures (electromyography and transcranial magnetic stimulation). The patients can quantify and identify more precisely the origin of fatigability (peripheral and central). This objective approach needs to be combined with the usual methods of measuring fatigue using valid and reliable patient-reported outcome measures. A quantitative measure of movement during walking must also be included to assess changes in fatigue during functional movement.
To quantify the proportion of fatigue associated with CMT1A, the investigators chose to compare data from patients with those of healthy subjects matched for age, height and lean body mass.
A better understanding of the role of fatigue in limiting walking and balance capacities in these patients will allow the investigators to refine the inpatient and outpatient management.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for patients:
- •Age ≥ 18 years and < 75 years
- •Patient with mCMT1A confirmed by genetic analysis (based on data recorded in the patient file)
- •Patient able to walk a minimum of 200 metres without a break, with or without equipment and/or technical aids (collected during questioning)
- •Patient able to get on and off a cycloergometer safely without assistance or with minimal assistance
- •Patient who has had a cardiological check-up before the stress test (ECG and cardiac ultrasound less than 6 months old) or for whom a check-up is scheduled before the inclusion
- •Patient affiliated to a health insurance scheme or beneficiary of such a scheme
- •Inclusion criteria for Healthy volunteers:
- •Age ≥ 18 years and < 75 years
- •Subject affiliated to or benefiting from a health insurance scheme
- •Subject who has had a cardiological work-up prior to stress testing (ECG and cardiac ultrasound less than 6 months old) or for whom a work-up is scheduled prior to the procedure.
排除标准
- •for patients:
- •Patients with all other forms of neuropathy (HNPP, other types of CMT, secondary neuropathies)
- •Patients with any of the following
- •An associated neurological disease other than mCMT1A
- •Severe joint disease of the lower limbs
- •Contraindication to isokinetic testing
- •Contraindication to an exercise stress test and exercise reconditioning program
- •A contraindication to Transcranial Magnetic Stimulation (TMS) : epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, unstable skull bone fracture, deafness, etc.
- •Patients who have undergone lower limb surgery in the 12 months prior to inclusion or for whom lower limb surgery is scheduled during the participation period.
- •Pregnant or breastfeeding or planning to become pregnant within the next 4 months
- •BMI > 35 kg/m2
- •Patient unable to give informed consent, unable to understand informed information
- •Subject under court protection
- •Subject under guardianship or curatorship
- •Subject in a period of exclusion (determined by a previous or current study)
- •Exclusion criteria for healthy volunteers:
- •History of neurological disease
- •Severe joint damage in the lower limbs
- •Any of the following
- •Contraindication to isokinetic testing
- •A contraindication to an exercise stress test and an exercise reconditioning program
- •A contraindication to TMS: epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, unstable skull bone fracture, deafness, etc.
- •Any person who has undergone surgery on the lower limbs in the 12 months prior to inclusion, or for whom surgery on the lower limbs is scheduled during the participation period.
- •Pregnant or breastfeeding, or planning to become pregnant within the next 4 months
- •Person unable to give informed consent, unable to understand informed information
- •BMI > 35 kg/m2
- •Person under legal protection
- •Person under guardianship or curatorship
- •Person in a period of exclusion (determined by a previous or current study)
研究组 & 干预措施
Charcot Marie Tooth type 1A
CLINICAL ASSESSMENT OF BODY FUNCTION (PROM AND PHYSICAL EXAMINATION):
- Perceived fatigue
- Mental functions
- Sensory functions and pain
- Neuromusculoskeletal and movement-related functions
- Functions of the cardiovascular and respiratory systems
o Exercise stress test
-
Fatigability (neuromuscular fatigue)
-
Lower limbs
-
Maximum voluntary strength
-
Study of the central and peripheral components of fatigue
ACTIVITIES AND PARTICIPATION
-
Mobility
-
Clinical standard tests for balance and walking
-
Quantified motion analysis
-
Activity level
-
Quality of life
干预措施: CLINICAL ASSESSMENT OF BODY FUNCTION (PROM AND PHYSICAL EXAMINATION) and ACTIVITIES AND PARTICIPATION (Other)
Healthy subjects matched for age, height and lean body mass.
Identical to patient, except for Charcot-Marie-Tooth specific tests
干预措施: CLINICAL ASSESSMENT OF BODY FUNCTION (PROM AND PHYSICAL EXAMINATION) and ACTIVITIES AND PARTICIPATION (Other)
结局指标
主要结局
Fatigability profile
时间窗: 7 days
Difference in isometric force developed by the knee extensors (assessment of overall neuromuscular fatigue) before and after a tiring exercise (stress test), during a maximum voluntary contraction, expressed in N.m-1, assessed on an isokinetic dynamometer (CONTREX®), compared between patients with mCMT1A and healthy volunteers.
次要结局
未报告次要终点