Association of Multiple Medications With the Severity of Dyspepsia
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 600
- 试验地点
- 4
- 主要终点
- The rate of patients with severe dyspepsia judged by patients
研究概览
简要总结
Dyspepsia is a very common gastrointestinal disease. Some medications, were associated with higher frequent incidences of dyspepsia, including non-steroid anti-inflammatory drugs (NSAIDs), Bisphosphonates, Tetracyclines, et al. Multiple medications were suggested to be strongly relate to adverse drug events (ADEs), adverse drug reactions (ADRs), drug-drug interactions, and drug-disease interactions, which may cause gastrointestinal(GI) dysfunction or injury to the GI mucosa. However, it was unclear whether multiple medications was associated with more severe symptoms of dyspepsia and dyspepsia-based score systems.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged ≥18 years old
- •Patients who met broad criteria of dyspepsia
排除标准
- •organ failure defined by Marshall standard
- •severe psychiatric illnesses
- •suspected or identified bowel obstruction
- •known malignancy
- •pregnancy or lactation
- •unable to provide consent
结局指标
主要结局
The rate of patients with severe dyspepsia judged by patients
时间窗: 1 day
Patients rated the severity of dyspepsia as mild, moderate, and severe by themselves
次要结局
- Global Overall Symptom score (GOSS)(1 days)
- subtypes of functional dyspepsia(6 months)
- Quality of Life scores(1 day)
- Functional dyspepsia(1 days)
- organic upper gastrointestinal (GI) diseases.(1 day)
- Short Form of Nepean Dyspepsia Index (SF-NDI)(1 day)
- Functional dyspepsia symptom diary (FDSD) score(1 days)
- Hospital anxiety and depression scale(1 day)
- Number of Participants with other functional gastrointestinal diseases(1 day)
研究者
Yanglin Pan
professor
Air Force Military Medical University, China