Retrospective Cohort Study of Patients With Type II (Hypercapnic) Respiratory Failure Treated With High-flow Oxygen Therapy Versus Non-invasive Ventilation With BiPAP
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 324
- 试验地点
- 1
- 主要终点
- Failure of initial treatment (combined outcome)
研究概览
简要总结
A retrospective cohort study of all patients treated for type II (hypercapnic) respiratory failure with either High-Flow Oxygen Therapy or Non-Invasive Ventilation in a general adult hospital.
详细描述
We will compare various clinically relevant outcomes in patients treated for type II (hypercapnic) acute respiratory failure (ARF) with either High-Flow Nasal Cannula (HFNC) or Non-Invasive Ventilation (NIV) in a general adult hospital.
All patients treated with HFNC were treated with an Optiflow device (Fisher&Paykel). Various Bilevel positive airway pressure (BiPAP) devices were used during the study period.
All ventilatory parameters were set according to the treating physicians' preferences.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients treated with respiratory failure not responding to conventional supplemental oxygen therapy
- •Blood venous gas showing partial pressure of carbon dioxide>50 mmHg before beginning therapy with either NIV or HFNC
排除标准
- •Lack of records of the primary outcome
- •End-of-life care
- •Lack of gas before the beginning of NIV or HFNC
结局指标
主要结局
Failure of initial treatment (combined outcome)
时间窗: 48 hours post intervention
Combined outcome of death or intubation or transition to another treatment modality or unplanned resumption of respiratory support
Death at 48h
时间窗: 48 hours post intervention
Mortality in the 48h following the initial intervention
次要结局
- Incidence of endotracheal intubation(For the whole length of hospital stay, up to a maximum of one year.)
- Length of stay(For the whole length of hospital stay, up to a maximum of one year.)
- Mortality at 7d(7 days post intervention)
- Duration of endotracheal intubation(For the whole length of hospital stay, up to a maximum of one year.)
- Incidence of intervention change(For the whole length of hospital stay, up to a maximum of one year.)