NCT03772457招募中不适用
To Explore the Predictive Value of Infarction Volume on Hemorrhagic Transformation in Newly Diagnosed Ischemic Stroke/TIA With Non-valve Atrial Fibrillation(NVAF) Patients Using Rivaroxaban
Second Affiliated Hospital, School of Medicine, Zhejiang University1 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2019年1月18日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Susceptibility weighted imaging(SWI) detection of newly developed hemorrhagic transformation after 14 days of rivaroxaban treatment
研究概览
简要总结
This study was aimed at patients with newly diagnosed stroke / TIA associated with nonvalvular atrial fibrillation. We will observe the effect of early using rivaroxaban anticoagulation on hemorrhagic transformation, and explore the predictive value of multi-mode MRI infarct volume / MMP-9 on hemorrhagic transformation after anticoagulation therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female, age≥18;
- •Were newly diagnosed asischemic stroke/TIA concomitant NVAF;
- •Prescribedand accept Rivaroxaban;
- •Sign thewritten informed consent.
排除标准
- •Renal impairment (CrCl<15 ml/min) or severe hepatic impairment.
- •Significant hemorrhagic transformation (parenchymal hematoma type I or type II by the ECASS definition).
- •Stroke or TIA caused by large artery atherosclerosis
- •Planned major surgery or invasive intervention
- •Active internal bleeding
- •Malignancy or other serious medical conditions with a life expectancy <6 months
- •Allergery to Rivaroxaban
- •Pregnancy or breast-feeding
结局指标
主要结局
Susceptibility weighted imaging(SWI) detection of newly developed hemorrhagic transformation after 14 days of rivaroxaban treatment
时间窗: 14 days after enrolling
次要结局
未报告次要终点
研究者
研究点 (1)
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