Narrowband Ultraviolet B Phototherapy in Children With Moderate to Severe Atopic Eczema- an Observational Prospective Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Moderate to Severe Atopic Eczema
- Sponsor
- Royal Victoria Infirmary
- Enrollment
- 58
- Locations
- 1
- Primary Endpoint
- Score at the end of treatment compared to the control group
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
To assess prospectively, the response of moderate to severe atopic eczema to a standard course of narrowband ultraviolet B phototherapy by using validated objective and subjective scoring systems.
Detailed Description
Children with moderate to severe atopic eczema prescribed a course of narrowband UVB phototherapy were scored (using validated scoring systems) objectively and subjectively before, during and after the course of treatment, as well as 3 and 6 months post treatment (to determine length of remission). Their scores were compared to a control group. The control group comprised children with moderate to severe atopic eczema who were offered UVB but were unable to undertake the treatment.
Investigators
Dr AEM Taylor
Consultant Dermatologist
Royal Victoria Infirmary
Eligibility Criteria
Inclusion Criteria
- •Children aged 3-16 years with moderate to severe atopic eczema (as defined by the modified Hannifin and Rajka criteria) in whom there is a clinical indication for phototherapy (as deemed by their specialist Dermatology consultant).
Exclusion Criteria
- •Children under the age of 3 years or any child who lacks the maturity needed to stand in the phototherapy cabinet unsupervised.
- •Mild disease (defined as a Six Area Six Sign Atopic Dermatitis (SASSAD) score \<10)
Outcomes
Primary Outcomes
Score at the end of treatment compared to the control group
Time Frame: 12 weeks
Measurement of Six Area Six Sign Atopic Dermatitis (SASSAD) score and percentage surface area affected of those treated with narrowband UVB as compared to a control group
Secondary Outcomes
- Subjective scores at the end of treatment as compared to controls(12 weeks)
- objective scores at 3 months post treatment compared to controls(3 months)
- Association of filaggrin status with outcome(12 weeks)
- Objective scores at 6 months post treatment compared to controls(6 months)
- Subjective scores at 3 months post treatment compared to controls(3 months)
- Subjective scores at 6 months post treatment compared to controls(6 months)