Narrowband Ultraviolet B Phototherapy in Children With Moderate to Severe Atopic Eczema- an Observational Prospective Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- Score at the end of treatment compared to the control group
研究概览
简要总结
To assess prospectively, the response of moderate to severe atopic eczema to a standard course of narrowband ultraviolet B phototherapy by using validated objective and subjective scoring systems.
详细描述
Children with moderate to severe atopic eczema prescribed a course of narrowband UVB phototherapy were scored (using validated scoring systems) objectively and subjectively before, during and after the course of treatment, as well as 3 and 6 months post treatment (to determine length of remission). Their scores were compared to a control group. The control group comprised children with moderate to severe atopic eczema who were offered UVB but were unable to undertake the treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children aged 3-16 years with moderate to severe atopic eczema (as defined by the modified Hannifin and Rajka criteria) in whom there is a clinical indication for phototherapy (as deemed by their specialist Dermatology consultant).
排除标准
- •Children under the age of 3 years or any child who lacks the maturity needed to stand in the phototherapy cabinet unsupervised.
- •Mild disease (defined as a Six Area Six Sign Atopic Dermatitis (SASSAD) score <10)
结局指标
主要结局
Score at the end of treatment compared to the control group
时间窗: 12 weeks
Measurement of Six Area Six Sign Atopic Dermatitis (SASSAD) score and percentage surface area affected of those treated with narrowband UVB as compared to a control group
次要结局
- Subjective scores at the end of treatment as compared to controls(12 weeks)
- objective scores at 3 months post treatment compared to controls(3 months)
- Association of filaggrin status with outcome(12 weeks)
- Objective scores at 6 months post treatment compared to controls(6 months)
- Subjective scores at 3 months post treatment compared to controls(3 months)
- Subjective scores at 6 months post treatment compared to controls(6 months)
研究者
Dr AEM Taylor
Consultant Dermatologist
Royal Victoria Infirmary