NCT00690950Unknown4 期
Switch Study: Are There Any Measurable Differences When Switching Patients on Finasteride Therapy to Dutasteride?
Urologic Consultants of Southeastern PA2 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2008年5月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Laboratory parameters: including serum testosterone, DHT level and PSA
研究概览
简要总结
Hypothesis: Dutasteride will perform better than finasteride in decreasing prostate volume, improving symptoms based on International Prostate Symptom score,and lower pvr based on the scientific information that dutasteride inhibits both Type I and II 5-alpha-reducatase vs. finasteride which only inhibits the Type II enzyme
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Age 50-80
- •On finasteride for no less than 12 months
- •Willing to undergo all necessary test in the 12 month evaluation
排除标准
- •History of medication non-compliance
- •Unwillingness to undergo/tolerate 2 blood draws
- •Unwillingness to tolerate/undergo 2 TRUSP
结局指标
主要结局
Laboratory parameters: including serum testosterone, DHT level and PSA
时间窗: 12 months
次要结局
- volume measurements of TRUSP and PVR(12 months)
- A decrease in the AUASI(12 months)
研究者
研究点 (2)
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