An Open-Label Study of the Safety and Efficacy of Intravitreal ISIS 2922 in Acquired Immune Deficiency Syndrome (AIDS) Patients With Cytomegalovirus Retinitis (NOTE: Restricted to Patients Who Rollover From Another Controlled ISIS 2922 Trial)
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 25
研究概览
简要总结
To evaluate the efficacy and safety of ISIS 2922 in AIDS patients with Cytomegalovirus ( CMV ) retinitis who are unresponsive or intolerant to ganciclovir and/or foscarnet but are otherwise ineligible for ISIS Pharmaceuticals' controlled trials OR who have failed ISIS 2922 therapy on another controlled clinical trial.
PER 2/8/96 AMENDMENT: Patients must rollover from another ISIS 2922 controlled trial.
详细描述
Patients receive intravitreal injections of ISIS 2922 at doses of either 150 or 300 mcg, depending on CMV retinitis location and extent of retinal involvement. There is a 3-week Induction period followed by at least 18 weeks of Maintenance. Induction is given on days 1, 8, and 15, and Maintenance doses are given every 14 days, beginning on day 29.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have:
- •CMV retinitis in one or both eyes that was previously treated but is presently uncontrolled.
- •Intolerance or resistance to other therapies.
排除标准
- •Co-existing Condition:
- •Patients with the following symptoms or conditions are excluded:
- •Eligibility to participate in a controlled clinical trial of ISIS
- •External ocular infection in eye to be treated.
- •Other herpetic infections of the retina, toxoplasma retinochoroiditis, or other diseases of the fundus in eye to be treated.
- •Ocular condition that would obstruct visualization of the posterior ocular structures in eye to be treated.
- •Retinal detachment in eye to be treated.
- •Known or suspected allergy to phosphorothioate oligonucleotides.
- •Silicone oil in eye to be treated.
- •Syphilis.
- •Clinical evidence of retinal pigment epithelial stippling.
- •Pseudoretinitis pigmentosa.
- •Concurrent Medication:
- •Foscarnet.
- •Mellaril, Stelazine, Thorazine, and Clofazimine.
- •Ethambutol / fluconazole combination.
- •Other investigational drugs for CMV retinitis.
- •Patients with the following prior conditions are excluded:
- •History of surgery to correct retinal detachment in eye to be treated.
- •History of ganciclovir implant for treatment of CMV retinitis.
- •History of intolerance to ISIS
- •History of syphilis.
- •Prior CMV retinitis therapy with ganciclovir, foscarnet, or ISIS 2922.